| Gene Symbol |
SUV420H2
|
| Entrez Gene |
84787
|
| Alt Symbol |
KMT5C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppressor of variegation 4-20 homolog 2 (Drosophila)
|
| Other Description |
histone-lysine N-methyltransferase SUV420H2|lysine N-methyltransferase 5C|su(var)4-20 homolog 2|suv4-20h2
|
| Swissprots |
Q9BRZ6 Q86Y97 Q8WZ10
|
| Accessions |
EAW72364 EAW72365 EAW72366 Q86Y97 AF289582 AAL55766 AK304562 BAH14216 AK308586 AW248704 BC005842 AAH05842 BC019313 AAH19313 BC044889 AAH44889 XM_005259338 XP_005259395 XM_006723442 XP_006723505 XM_011527415 XP_011525717 XM_011527416 XP_011525718 NM_032701 NP_116090
|
| Function |
Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.
|
| Top Pathways |
Lysine degradation
|