SUV420H2

Gene Symbol SUV420H2
Entrez Gene 84787
Alt Symbol KMT5C
Species Human
Gene Type protein-coding
Description suppressor of variegation 4-20 homolog 2 (Drosophila)
Other Description histone-lysine N-methyltransferase SUV420H2|lysine N-methyltransferase 5C|su(var)4-20 homolog 2|suv4-20h2
Swissprots Q9BRZ6 Q86Y97 Q8WZ10
Accessions EAW72364 EAW72365 EAW72366 Q86Y97 AF289582 AAL55766 AK304562 BAH14216 AK308586 AW248704 BC005842 AAH05842 BC019313 AAH19313 BC044889 AAH44889 XM_005259338 XP_005259395 XM_006723442 XP_006723505 XM_011527415 XP_011525717 XM_011527416 XP_011525718 NM_032701 NP_116090
Function Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). {ECO:0000250}.
Subcellular Location Nucleus. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.
Top Pathways Lysine degradation

SUV420H2 CRISPR/Cas9 KO Plasmid (h) - sc-404626 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV420H2 HDR Plasmid (h) - sc-404626-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV420H2 Double Nickase Plasmid (h) - sc-404626-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV420H2 Double Nickase Plasmid (h2) - sc-404626-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV420H2 CRISPR Activation Plasmid (h) - sc-404626-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV420H2 CRISPR Activation Plasmid (h2) - sc-404626-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV420H2 Lentiviral Activation Particles (h) - sc-404626-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV420H2 Lentiviral Activation Particles (h2) - sc-404626-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV420H2 siRNA (h) - sc-97240 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SUV420H2 shRNA Plasmid (h) - sc-97240-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SUV420H2 shRNA (h) Lentiviral Particles - sc-97240-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU097791 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20860 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20860 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05654 from Sigma-Aldrich

Category miRNA

SUV420H2 siRNA (Human) - CRJ3619 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SUV420H2 - MBS8220851 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SUV420H2 CRISPR/Cas9 KO Plasmid (h2) - sc-404626-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SUV420H2 HDR Plasmid (h2) - sc-404626-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human SUV420H2 (NM_032701.3) - SHH421220 from Creative biogene

Category siRNA
Species Reactivities Human

Human SUV420H2 siRNA - orb274120 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SUV420H2 shRNA Plasmid (Human) - CHJ3619 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SUV420H2 miRNA 3'UTR clone - MiUTR4H-TG08686 from Creative biogene

Species Reactivities Human
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