CCRN4L

Gene Symbol	CCRN4L
Entrez Gene	25819
Alt Symbol	CCR4L, Ccr4c, NOC
Species	Human
Gene Type	protein-coding
Description	CCR4 carbon catabolite repression 4-like (S. cerevisiae)
Other Description	CCR4 protein homolog|CCR4-like (carbon catabolite repression 4, S.cerevisiae)|carbon catabolite repression 4-like protein|circadian deadenylase NOC|nocturnin
Swissprots	Q9HD95 Q9UK39 D3DNY5 Q9HD94 Q9HD93 Q14D51
Accessions	AAG01387 EAX05129 EAX05130 EAX05131 Q9UK39 AF183961 AAD56548 AF199493 AAG01388 AF199494 AAG01389 BC021963 AAH21963 BC023512 AAH23512 BC077723 AAH77723 BC113494 AAI13495 BC113500 AAI13501 HY067201 NM_012118 NP_036250
Function	Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase- independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.
Tissue Specificity	Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue. {ECO:0000269|PubMed:22331129}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Nocturnin (F-4) - sc-376584 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Nocturnin (H-120) - sc-135002 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Nocturnin (E-15) - sc-65153 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Nocturnin (P-16) - sc-65154 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-CCRN4L / Nocturnin Antibody (clone 3E8) - LS-C105127 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3E8

Anti-CCRN4L / Nocturnin Antibody (aa82-131) - LS-C31030 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CCRN4L / Nocturnin Antibody (aa309-336) - LS-C99343 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Nocturnin Antibody (3E8) - H00025819-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3E8

Nocturnin Antibody - NBP2-37939 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Nocturnin Antibody - NBP2-37856 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Nocturnin Antibody - H00025819-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Nocturnin Polyclonal Antibody - bs-11444R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Nocturnin Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11444R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Nocturnin Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11444R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Nocturnin Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11444R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Nocturnin Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11444R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Nocturnin Polyclonal Antibody, Cy3 Conjugated - bs-11444R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Nocturnin Polyclonal Antibody, Cy5 Conjugated - bs-11444R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Nocturnin Polyclonal Antibody, Cy5.5 Conjugated - bs-11444R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Nocturnin Polyclonal Antibody, Cy7 Conjugated - bs-11444R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Nocturnin Polyclonal Antibody, FITC Conjugated - bs-11444R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Nocturnin Polyclonal Antibody, Biotin Conjugated - bs-11444R-Biotin from Bioss Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Nocturnin Polyclonal Antibody, HRP Conjugated - bs-11444R-HRP from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ANTI-CCRN4L(C-TERMINAL) antibody produced in rabbit - SAB1307201 from Sigma-Aldrich Prices $326.00 Sizes 40 tst Host Rabbit Clonality Polyclonal

Monoclonal Anti-CCRN4L antibody produced in mouse - WH0025819M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3E8

Search more