| Gene Symbol |
CCRN4L
|
| Entrez Gene |
25819
|
| Alt Symbol |
CCR4L, Ccr4c, NOC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CCR4 carbon catabolite repression 4-like (S. cerevisiae)
|
| Other Description |
CCR4 protein homolog|CCR4-like (carbon catabolite repression 4, S.cerevisiae)|carbon catabolite repression 4-like protein|circadian deadenylase NOC|nocturnin
|
| Swissprots |
Q9HD95 Q9UK39 D3DNY5 Q9HD94 Q9HD93 Q14D51
|
| Accessions |
AAG01387 EAX05129 EAX05130 EAX05131 Q9UK39 AF183961 AAD56548 AF199493 AAG01388 AF199494 AAG01389 BC021963 AAH21963 BC023512 AAH23512 BC077723 AAH77723 BC113494 AAI13495 BC113500 AAI13501 HY067201 NM_012118 NP_036250
|
| Function |
Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase- independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.
|
| Tissue Specificity |
Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue. {ECO:0000269|PubMed:22331129}.
|