CCRN4L

Gene Symbol CCRN4L
Entrez Gene 25819
Alt Symbol CCR4L, Ccr4c, NOC
Species Human
Gene Type protein-coding
Description CCR4 carbon catabolite repression 4-like (S. cerevisiae)
Other Description CCR4 protein homolog|CCR4-like (carbon catabolite repression 4, S.cerevisiae)|carbon catabolite repression 4-like protein|circadian deadenylase NOC|nocturnin
Swissprots Q9HD95 Q9UK39 D3DNY5 Q9HD94 Q9HD93 Q14D51
Accessions AAG01387 EAX05129 EAX05130 EAX05131 Q9UK39 AF183961 AAD56548 AF199493 AAG01388 AF199494 AAG01389 BC021963 AAH21963 BC023512 AAH23512 BC077723 AAH77723 BC113494 AAI13495 BC113500 AAI13501 HY067201 NM_012118 NP_036250
Function Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase- independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.
Tissue Specificity Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue. {ECO:0000269|PubMed:22331129}.

Nocturnin CRISPR/Cas9 KO Plasmid (h) - sc-405350 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nocturnin HDR Plasmid (h) - sc-405350-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nocturnin Double Nickase Plasmid (h) - sc-405350-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nocturnin Double Nickase Plasmid (h2) - sc-405350-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nocturnin CRISPR Activation Plasmid (h) - sc-405350-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nocturnin CRISPR Activation Plasmid (h2) - sc-405350-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nocturnin Lentiviral Activation Particles (h) - sc-405350-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nocturnin Lentiviral Activation Particles (h2) - sc-405350-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nocturnin siRNA (h) - sc-62697 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nocturnin shRNA Plasmid (h) - sc-62697-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nocturnin shRNA (h) Lentiviral Particles - sc-62697-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nocturnin RNAi - H00025819-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU050861 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5663 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04453 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04453

CCRN4L siRNA (Human) - CRH8518 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CCRN4L - MBS8208060 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CCRN4L(NM_012118.2) - SHG153439 from Creative biogene

Category siRNA
Species Reactivities Human

Human CCRN4L siRNA - orb269020 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CCRN4L shRNA Plasmid (Human) - CHH8518 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CCRN4L miRNA 3'UTR clone - MiUTR1H-01831 from Creative biogene

Species Reactivities Human
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