PIWIL1

Gene Symbol	PIWIL1
Entrez Gene	9271
Alt Symbol	CT80.1, HIWI, MIWI, PIWI
Species	Human
Gene Type	protein-coding
Description	piwi-like RNA-mediated gene silencing 1
Other Description	piwi homolog|piwi-like protein 1
Swissprots	Q96JD5 Q8TBY5 Q96J94 A4F266 Q8NA60 O95404
Accessions	CBH19412 CBH30591 EAW98509 EAW98510 EAW98511 Q96J94 AB274731 BAF49084 AF104260 AAC97371 AF264004 AAK92281 AF387507 AAK69348 AK093133 BAC04068 BC028581 AAH28581 BG718140 DB072454 DB527532 JF432823 ADZ16040 XM_005253632 XP_005253689 XM_006719698 XP_006719761 XM_011539002 XP_011537304 XM_011539003 XP_011537305 XM_011539004 XP_011537306 XM_011539005 XP_011537307 XM_011539006 XP_011537308 XM_011546618 XP_011544920 XM_011546619 XP_011544921 XM_011546620 XP_011544922 XM_011546621 XP_011544923 XR_944838 XR_944839 NM_001190971 NP_001177900 NM_004764 NP_004755
Function	Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative dev
Subcellular Location	Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in spermatocytes and spermatids. Also detected in prostate cancer (at protein level). Detected in most fetal and adult tissues. Expressed in testes, specifically in germline cells; detected in spermatocytes and spermatids during spermatogenesis. Increased expression in testicular tumors originating from embryonic germ cells with retention of germ cells phenotype. No expression in testicular tumors of somatic origin, such as Sertoli cell and Leydig cell tumors. Overexpressed in gastric cancer cells. Isoform 3 is ubiquitously expressed, and specifically in CD34+ hematopoietic progenitor cells but not in more differentiated cells. {ECO:0000269|PubMed:11154219, ECO:0000269|PubMed:12037681, ECO:0000269|PubMed:12906857, ECO:0000269|PubMed:23436708}.
Top Pathways	Dorso-ventral axis formation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PIWIL1 peptide - ab13827 from Abcam Category Peptide

Human PIWIL1 protein fragment - ab152968 from Abcam Category Protein Source Wheat germ Species Human

Piwi peptide - ab14803 from Abcam Category Peptide

PIWIL1 / PIWI Antibody Blocking Peptide - LS-E31022 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PIWIL1 / PIWI Antibody Blocking Peptide - LS-E25844 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIWIL1 / PIWI Antibody Blocking Peptide - LS-E15206 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PIWIL1 / PIWI Antibody Blocking Peptide - LS-E15207 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PIWIL1/HIWI Protein - H00009271-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PIWIL1/HIWI Blocking Peptide - NBP1-76489PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

PIWIL1 blocking peptide - GTX89021-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

PIWIL1 Blocking Peptide - 33R-5494 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PIWIL1 Blocking Peptide - 33R-3029 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PIWIL1 Peptide - AC21-0676-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PIWIL1 - H00009271-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PIWIL1 - H00009271-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PIWIL1 control peptide - AP26292CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

HIWI Peptide - 45-735P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

PIWI-L1 Peptide - 6029P from ProSci Category Peptide Species Human

PIWIL1 fusion protein - Ag8056 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PIWIL1 fusion protein - ag5081 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PIWIL1, His-tagged - PIWIL1-1736H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Piwi-like protein 1(PIWIL1) ,partial - CSB-YP846642HU CSB-EP846642HU CSB-BP846642HU CSB-MP846642HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PIWIL1 Protein - abx163029 from Abbexa Category Protein Species Human

Piwi-like protein 1 (PIWIL1), partial, Recombinant Protein - MBS1392362 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PIWI/HIWI, Peptide - MBS425059 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig

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