HIST1H2B8

Gene Symbol HIST1H2B8
Entrez Gene 427886
Alt Symbol H2B-VIII, HIST1H2BO
Species Chicken
Gene Type protein-coding
Description histone cluster 1, H2B-VIII
Other Description H2B VIII|histone H2B 8|histone cluster 1, H2bo
Swissprots Q9PSW9
Accessions BAA23985 CAA30588 CAR80248 CBX83706 Q9PSW9 NM_001031481 NP_001026652
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Subcellular Location Nucleus. Chromosome.

Anti-Histone H2B (acetyl K12) antibody - ab118582 from Abcam

Prices $407.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Human Breast (formalin-fixed, paraffin-embedded) stained with ab118582 at 1/100 followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Histone H2B (acetyl K16) antibody - ChIP Grade - ab40977 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Histone H2B (acetyl K16) antibody - ChIP Grade (ab40977) at 1 µg/mlLane 1 : HeLa Histone Preparation Nuclear LysateLane 2 : HeLa Histone Preparation Nuclear Lysate - Butyrated treated Lane 3 : HeLa Histone Preparation Nuclear Lysate with Human Histone H2B (acetyl K16) peptide (ab41879) at 1 µg/mlLane 4 : HeLa Histone Preparation Nuclear Lysate - Butyrated treated with Human Histone H2B (acetyl K16) peptide (ab41879) at 1 µg/mlLane 5 : HeLa Histone Preparation Nuclear Lysate with Human Histone H2B peptide (ab35793) at 1 µg/mlLane 6 : HeLa Histone Preparation Nuclear Lysate - Butyrated treated with Human Histone H2B peptide (ab35793) at 1 µg/mlLysates/proteins at 2.5 µg per lane.SecondaryHRP Conjugated Goat Anti-Rabbit IgG at 1/3000 dilutionPerformed under reducing conditions.

Anti-Histone H2B (acetyl K85) antibody - ab4630 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC image of ab4630 staining Histone H2B (acetyl K85) in human colon formalin fixed paraffin embedded tissue sections, performed on a Leica Bond. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab4630, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. No primary antibody was used in the negative control (shown on the inset).For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.
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