| Gene Symbol |
TBL1Y
|
| Entrez Gene |
90665
|
| Alt Symbol |
TBL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transducin (beta)-like 1, Y-linked
|
| Other Description |
F-box-like/WD repeat-containing protein TBL1Y|transducin beta-like 1|transducin beta-like protein 1Y|transducin-beta-like protein 1, Y-linked
|
| Swissprots |
A1L4B3 Q9BQ87
|
| Accessions |
ACP43287 ACP43288 ACP43289 EAW59126 EAW59127 EAW59128 Q9BQ87 AF332220 AAK13472 AF332221 AAK13473 AF332222 AAK13474 AK056903 AK298210 BAG60480 BC130471 AAI30472 BC130473 AAI30474 HQ258280 ADR83034 XM_005262572 XP_005262629 NM_033284 NP_150600 NM_134258 NP_599020 NM_134259 NP_599021
|
| Function |
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Fetal brain and prostate. {ECO:0000269|PubMed:12815422}.
|
| Top Pathways |
Wnt signaling pathway
|