| Gene Symbol |
BVES
|
| Entrez Gene |
408032
|
| Alt Symbol |
POP1, POPDC1
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
blood vessel epicardial substance
|
| Other Description |
POP1C protein|popeye domain-containing protein 1|popeye protein 1
|
| Swissprots |
Q9DG23 Q9DG20 Q9PWC0 Q9DG22 Q9DG21
|
| Accessions |
Q9DG23 AF124511 AAD51779 AF208398 AAG23410 AF208399 AAG23411 CR389275 CR407038 NM_001001299 NP_001001299
|
| Function |
Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. Involved in epithelial movement during corneal sheet formation and regeneration. May play a role in VAMP3- mediated vesicular transport and recycling of receptor molecules. May play a role in the regulation of cell shape and movement by modulating the Rho-GTPase activity. May also be involved in striated muscle regeneration and in the regulation of cell spreading. {ECO:0000269|PubMed:15277466, ECO:0000269|PubMed:16188940}.
|
| Subcellular Location |
Lateral cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Detected at points of cell-cell contact in confluent epithelial sheets. Colocalizes with components of the adherens and tight junctions. {ECO:0000269|PubMed:15277466, ECO:0000269|PubMed:16188940, ECO:0000269|PubMed:18493308}.
|
| Tissue Specificity |
Expressed in the heart and skeletal muscle (at protein level). Isoform 1 and isoform 4: expressed in heart, muscle, brain, stomach, kidney, lung and spleen. {ECO:0000269|PubMed:10208750, ECO:0000269|PubMed:10882522, ECO:0000269|PubMed:15277466}.
|