| Gene Symbol |
KLRG1
|
| Entrez Gene |
10219
|
| Alt Symbol |
2F1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, MAFA-LIKE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
killer cell lectin-like receptor subfamily G, member 1
|
| Other Description |
C-type lectin domain family 15 member A|C-type lectin domain family 15, member A|ITIM-containing receptor MAFA-L|MAFA-like receptor|killer cell lectin-like receptor subfamily G member 1|mast cell function-associated antigen (ITIM-containing)
|
| Swissprots |
O75613 B7ZAM2 O43198 Q96E93
|
| Accessions |
EAW88594 EAW88595 Q96E93 AF034952 AAC34731 AF081675 AAC32200 AF097358 AAD03719 AI433079 AK301367 BAG62909 AK316337 BAH14708 BC012621 AAH12621 DQ892820 ABM83746 DQ896066 ABM87065 NM_005810 NP_005801
|
| Function |
Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. {ECO:0000269|PubMed:19604491}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:19604491}; Single-pass type II membrane protein {ECO:0000269|PubMed:19604491}.
|
| Tissue Specificity |
Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells. {ECO:0000269|PubMed:15879103, ECO:0000269|PubMed:9842918}.
|