Gene Symbol | KLRG1 |
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Entrez Gene | 10219 |
Alt Symbol | 2F1, CLEC15A, MAFA, MAFA-2F1, MAFA-L, MAFA-LIKE |
Species | Human |
Gene Type | protein-coding |
Description | killer cell lectin-like receptor subfamily G, member 1 |
Other Description | C-type lectin domain family 15 member A|C-type lectin domain family 15, member A|ITIM-containing receptor MAFA-L|MAFA-like receptor|killer cell lectin-like receptor subfamily G member 1|mast cell function-associated antigen (ITIM-containing) |
Swissprots | O75613 B7ZAM2 O43198 Q96E93 |
Accessions | EAW88594 EAW88595 Q96E93 AF034952 AAC34731 AF081675 AAC32200 AF097358 AAD03719 AI433079 AK301367 BAG62909 AK316337 BAH14708 BC012621 AAH12621 DQ892820 ABM83746 DQ896066 ABM87065 NM_005810 NP_005801 |
Function | Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. {ECO:0000269|PubMed:19604491}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:19604491}; Single-pass type II membrane protein {ECO:0000269|PubMed:19604491}. |
Tissue Specificity | Expressed specifically on natural killer (NK) cells and T-cells, mainly CD8 T-cells. {ECO:0000269|PubMed:15879103, ECO:0000269|PubMed:9842918}. |
KLRG1 CRISPR/Cas9 KO Plasmid (h) - sc-409220 from Santa Cruz Biotechnology
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KLRG1 HDR Plasmid (h) - sc-409220-HDR from Santa Cruz Biotechnology
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KLRG1 Double Nickase Plasmid (h) - sc-409220-NIC from Santa Cruz Biotechnology
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KLRG1 Double Nickase Plasmid (h2) - sc-409220-NIC-2 from Santa Cruz Biotechnology
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KLRG1 CRISPR Activation Plasmid (h) - sc-409220-ACT from Santa Cruz Biotechnology
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KLRG1 CRISPR Activation Plasmid (h2) - sc-409220-ACT-2 from Santa Cruz Biotechnology
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KLRG1 Lentiviral Activation Particles (h) - sc-409220-LAC from Santa Cruz Biotechnology
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KLRG1 Lentiviral Activation Particles (h2) - sc-409220-LAC-2 from Santa Cruz Biotechnology
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KLRG1 siRNA (h) - sc-42937 from Santa Cruz Biotechnology
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KLRG1 shRNA Plasmid (h) - sc-42937-SH from Santa Cruz Biotechnology
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KLRG1 shRNA (h) Lentiviral Particles - sc-42937-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU061281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11329 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11329 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08934 from Sigma-Aldrich
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KLRG1 siRNA (Human) - CRH6908 from Cohesion Biosciences
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KLRG1 RNAi - H00010219-R02 from Novus Biologicals
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shRNA set against Human KLRG1 (NM_005810.3) - SHH326871 from Creative biogene
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shRNA set against Human KLRG1(NM_005810.3) - SHH138359 from Creative biogene
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Human KLRG1 siRNA - orb267410 from Biorbyt
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KLRG1 shRNA Plasmid (Human) - CHH6908 from Cohesion Biosciences
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KLRG1 miRNA 3'UTR clone - MiUTR1H-05419 from Creative biogene
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