| Gene Symbol | Polr1a |
|---|---|
| Entrez Gene | 20019 |
| Alt Symbol | 194kDa, 3010014K16Rik, RPA194, Rpo1-4, mRPA1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | polymerase (RNA) I polypeptide A |
| Other Description | DNA-directed RNA polymerase I largest subunit|DNA-directed RNA polymerase I subunit A|DNA-directed RNA polymerase I subunit RPA1|RNA polymerase 1-4 (194 kDa subunit)|RNA polymerase I 194 kDa subunit|RNA polymerase I subunit A1 |
| Swissprots | O35134 Q7TSA9 |
| Accessions | EDK98958 O35134 AF000938 AAB66718 AK031689 AK045809 BAC32498 AK077818 AK082883 BAC38667 AK087773 BAC39997 AK134239 BAE22059 AK147379 BAE27874 AK160785 BAE36009 AK160970 BAE36122 AK178488 AK185409 BC010254 AAH10254 BC034785 AAH34785 BC049190 AAH49190 BC053744 AAH53744 CJ260853 XM_006505804 XP_006505867 NM_009088 NP_033114 |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus, nucleolus {ECO:0000250}. |
| Top Pathways | Purine metabolism, RNA polymerase, Pyrimidine metabolism |