LIN7A

Gene Symbol	LIN7A
Entrez Gene	8825
Alt Symbol	LIN-7A, LIN7, MALS-1, TIP-33, VELI1
Species	Human
Gene Type	protein-coding
Description	lin-7 homolog A (C. elegans)
Other Description	hLin-7|mammalian LIN-7 1|mammalian lin-seven protein 1|protein lin-7 homolog A|tax interaction protein 33|veli-1|vertebrate LIN7 homolog 1|vertebrate lin-7 homolog 1
Swissprots	Q6LES3 A4FTY3 O14910 Q147W1 Q7LDS4
Accessions	EAW97370 EAW97371 O14910 AF028826 AAB84251 AF087693 AAC78481 AF173081 AAD48500 AK022997 AK309256 AK315321 BAG37724 BC041400 BC046926 BC062332 BC099921 AAH99921 BC118609 AAI18610 BC122561 AAI22562 CR407680 CAG28608 XM_011538928 XP_011537230 NM_004664 NP_004655
Function	Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000269|PubMed:12967566}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Basolateral cell membrane {ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000269|PubMed:12967566}. Cell junction {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. {ECO:0000250}.
Tissue Specificity	Expressed in brain, testis, kidney, placenta and liver. {ECO:0000269|PubMed:11311936}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Veli1 (Q-14) - sc-11496 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Veli1/2/3 (C-15) - sc-11499 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-LIN7A antibody - ab130669 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-LIN7A antibody [EPR12609] - ab174297 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR12609

Anti-LIN7A Antibody (N-Terminus) - LS-C153529 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LIN7A Antibody (aa180-207, FITC) - LS-C261934 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIN7A Antibody (aa180-207, AP) - LS-C261932 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIN7A Antibody (aa180-207, PE) - LS-C261936 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIN7A Antibody (aa180-207, APC) - LS-C261931 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIN7A Antibody (aa180-207, Azide-free, HRP) - LS-C261935 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIN7A Antibody (aa180-207, Biotin) - LS-C261933 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIN7A Antibody - LS-C308758 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-LIN7A Antibody (aa179-207) - LS-C322666 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LIN7A Antibody (aa180-207) - LS-C160051 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

LIN7 Antibody - NBP2-15016 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LIN7 Antibody - NBP1-70368 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LIN7 Antibody - NBP1-70367 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

LIN7 Antibody - H00008825-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-LIN7A antibody produced in mouse - SAB1401441 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-LIN7A antibody produced in rabbit - SAB2701306 from Sigma-Aldrich Prices $326.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-LIN-7 antibody produced in rabbit - L1538 from Sigma-Aldrich Prices $372.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

LIN7A-Antibody-C-term - AP17246b from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

LIN7A antibody [GT377] - GTX631106 from GeneTex Prices $119.00 Sizes 25 μl Host Mouse Clonality Monoclonal Clone GT377

LIN7A antibody [GT879] - GTX631107 from GeneTex Prices $119.00 Sizes 25 μl Host Mouse Clonality Monoclonal Clone GT879

LIN7A antibody [N1C3] - GTX117114 from GeneTex Prices $119.00 Sizes 25 μl Host Rabbit Clonality Polyclonal

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