IRF2

Gene Symbol IRF2
Entrez Gene 3660
Alt Symbol IRF-2
Species Human
Gene Type protein-coding
Description interferon regulatory factor 2
Other Description -
Swissprots P14316 Q6IAS7 D6RCK5 H0Y8S3 Q96B99
Accessions CCQ43169 EAX04677 EAX04678 EAX04679 EAX04680 P14316 AA361545 AK312953 BAG35793 BC015803 AAH15803 BP200998 BQ017798 BT007264 AAP35928 BX648934 CR457077 CAG33358 DQ409328 X15949 CAA34073 XM_005262984 XP_005263041 XM_005262986 XP_005263043 XM_011531928 XP_011530230 XM_011531929 XP_011530231 NM_002199 NP_002190
Function Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. {ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:18514056, ECO:0000269|PubMed:9540062}.
Subcellular Location Nucleus.
Tissue Specificity Expressed throughout the epithelium of the colon. Also expressed in lamina propria. {ECO:0000269|PubMed:15226432}.

IRF-2 Antibody - 4943 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from SR, Ramos and A20 cells using IRF-2 Antibody.

IRF-2 (G-10) - sc-374327 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IRF-2 (G-10): sc-374327. Western blot analysis of IRF-2 expression in non-transfected: sc-117752 (A) and mouse IRF-2 transfected: sc-121108 (B) 293T whole cell lysates.

IRF-2 (C-19) - sc-498 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IRF-2 (C-19): sc-498. Western blot analysis of IRF-2 expression in Jurkat (A) and MM-142 (B) whole cell lysates.

IRF-2 (H-17) - sc-30893 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IRF-2 (H-17): sc-30893. Western blot analysis of IRF-2 expression in MM-142 nuclear extract (A) and MM-142 (B) and HeLa (C) whole cell lysates.

IRF-2 (G-20) - sc-30894 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IRF-2 (H-229) - sc-13042 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IRF-2 (H-229): sc-13042. Western blot analysis of IRF-2 expression in non-transfected: sc-117752 (A) and human IRF-2 transfected: sc-112233 (B) 293T whole cell lysates.

IRF-2 (TQ-5) - sc-101069 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IRF-2 (TQ-5): sc-101069. Western blot analysis of IRF-2 expression in HeLa whole cell lysate.

Anti-IRF2 antibody - ab55331 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-IRF2 antibody - ab169312 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-IRF2 antibody (ab169312) at 1 µg/mlLane 1 : IRF2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-IRF2 antibody - ab55333 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
IRF2 antibody (ab55333) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human leiomyosarcoma.

Anti-IRF2 antibody - ab65048 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab65048 at 1/50 dilution staining IRF2 in human colon carcinoma by Immunohistochemistry, Paraffin-embedded tissue, in the absence or presence of the immunising peptide.

Anti-IRF2 antibody - ab86018 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IRF2 antibody (ab86018) at 1/1000 dilutionLane 1 : Uninduced (negative control) culture of E.coli Lane 2 : Induced culture of E.coli Secondaryanti-Rabbit IgG HRP conjugated at 1/1000 dilution

Anti-IRF2 antibody - ab3388 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-IRF2 antibody [EPR4644(2)] - ab124744 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4644(2)
Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized HeLa (Human epithelial cells from cervix adenocarcinoma) cells labeling IRF2 with ab124744 at 1/500 dilution, followed by Goat anti-rabbit IgG (Alexa Fluor® 488) (ab150077) secondary antibody at 1/500 dilution (green). Confocal image showing nuclear staining on HeLa cells.The nuclear counter stain is DAPI (blue). Tubulin is detected with ab7291 (anti-Tubulin mouse mAb) at 1/1000 dilution and ab150120 (AlexaFluor®594 Goat anti-Mouse secondary) at 1/500 dilution (red).The negative controls are as follows:-ve control 1: ab124744 at 1/500 dilution followed by ab150120 (AlexaFluor®594 Goat anti-Mouse secondary) at 1/500 dilution.-ve control 2: ab7291 (anti-Tubulin mouse mAb) at 1/1000 dilution followed by ab150077 (Alexa Fluor®488 Goat Anti-Rabbit IgG H&L) at 1/500 dilution. 

Anti-IRF2 Antibody (clone 3B5) - LS-C133274 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B5
Immunoperoxidase of monoclonal antibody to IRF2 on formalin-fixed paraffin-embedded human leiomyosarcoma. [antibody concentration 3 ug/ml]

Anti-IRF2 Antibody (aa151-349) - LS-C36963 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-IRF2 Antibody (Asp327) - LS-C36962 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-IRF2 Antibody (clone 198C4a) - LS-C184806 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 198C4a

Anti-IRF2 Antibody (aa225-255, AP) - LS-C260365 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRF2 Antibody (aa225-255, APC) - LS-C260366 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRF2 Antibody (aa91-140) - LS-C30832 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-IRF2 Antibody (aa52-101) - LS-C29821 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-IRF2 Antibody (aa225-255, Biotin) - LS-C260367 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRF2 Antibody (aa225-255, FITC) - LS-C260368 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IRF2 Antibody (aa225-255, Azide-free, HRP) - LS-C260369 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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