Gene Symbol | CHRNA2 |
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Entrez Gene | 1135 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | cholinergic receptor, nicotinic, alpha 2 (neuronal) |
Other Description | acetylcholine receptor, nicotinic, alpha 2 (neuronal)|cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)|neuronal acetylcholine receptor subunit alpha-2 |
Swissprots | J3KMY9 Q9HAQ3 Q15822 B4DK19 A8KAX3 |
Accessions | EAW63552 Q15822 AK296348 BAG59031 AK308465 AK314787 AW292180 BC153866 AAI53867 CD013901 DA096824 DA407151 U62431 AAB40109 Y16281 CAA76154 XM_005273397 XP_005273454 XM_006716282 XP_006716345 XM_011544388 XP_011542690 XM_011544389 XP_011542691 NM_000742 NP_000733 NM_001282455 NP_001269384 |
Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
Top Pathways | Neuroactive ligand-receptor interaction |
AChRα2 CRISPR/Cas9 KO Plasmid (h) - sc-403376 from Santa Cruz Biotechnology
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AChRα2 HDR Plasmid (h) - sc-403376-HDR from Santa Cruz Biotechnology
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AChRα2 Double Nickase Plasmid (h) - sc-403376-NIC from Santa Cruz Biotechnology
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AChRα2 Double Nickase Plasmid (h2) - sc-403376-NIC-2 from Santa Cruz Biotechnology
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AChRα2 CRISPR Activation Plasmid (h) - sc-403376-ACT from Santa Cruz Biotechnology
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AChRα2 CRISPR Activation Plasmid (h2) - sc-403376-ACT-2 from Santa Cruz Biotechnology
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AChRα2 Lentiviral Activation Particles (h) - sc-403376-LAC from Santa Cruz Biotechnology
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AChRα2 Lentiviral Activation Particles (h2) - sc-403376-LAC-2 from Santa Cruz Biotechnology
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AChRα2 siRNA (h) - sc-42526 from Santa Cruz Biotechnology
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AChRα2 shRNA Plasmid (h) - sc-42526-SH from Santa Cruz Biotechnology
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AChRα2 shRNA (h) Lentiviral Particles - sc-42526-V from Santa Cruz Biotechnology
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Nicotinic Acetylcholine R alpha 2/CHRNA2 RNAi - H00001135-R01 from Novus Biologicals
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MISSION® esiRNA - EHU120491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6097 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6097 from Sigma-Aldrich
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CHRNA2 siRNA (Human) - CRH0812 from Cohesion Biosciences
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CHRNA2 - MBS829928 from MyBioSource
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shRNA set against Human CHRNA2 (NM_000742.3) - SHH263537 from Creative biogene
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shRNA set against Human CHRNA2(NM_000742.3) - SHG177577 from Creative biogene
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Human CHRNA2 siRNA - orb261314 from Biorbyt
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CHRNA2 shRNA Plasmid (Human) - CHH0812 from Cohesion Biosciences
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CHRNA2 miRNA 3'UTR clone - MiUTR1H-02142 from Creative biogene
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