| Gene Symbol |
PHF2
|
| Entrez Gene |
5253
|
| Alt Symbol |
CENP-35, GRC5, JHDM1E
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PHD finger protein 2
|
| Other Description |
centromere protein 35|jumonji C domain-containing histone demethylase 1E|lysine-specific demethylase PHF2
|
| Swissprots |
Q4VXG0 Q9Y6N4 O75151 Q8N3K2
|
| Accessions |
EAW62867 EAW62868 EAW62869 EAW62870 EAW62871 O75151 AB014562 BAA31637 AF043725 AAD21791 AK294861 BAG57965 AL834263 CAD38938 BC028051 AAH28051 BC050112 BC064613 AAH64613 BC152437 BC172253 AAI72253 BC172560 AAI72560 BQ716020 BU507256 CB990295 XM_005252051 XP_005252108 XM_006717143 XP_006717206 XM_011518784 XP_011517086 NM_005392 NP_005383 NM_024517
|
| Function |
Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. {ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:20129925}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.
|
| Tissue Specificity |
Widely expressed, including in liver (at protein level). {ECO:0000269|PubMed:21532585}.
|