PHF2

Gene Symbol PHF2
Entrez Gene 5253
Alt Symbol CENP-35, GRC5, JHDM1E
Species Human
Gene Type protein-coding
Description PHD finger protein 2
Other Description centromere protein 35|jumonji C domain-containing histone demethylase 1E|lysine-specific demethylase PHF2
Swissprots Q4VXG0 Q9Y6N4 O75151 Q8N3K2
Accessions EAW62867 EAW62868 EAW62869 EAW62870 EAW62871 O75151 AB014562 BAA31637 AF043725 AAD21791 AK294861 BAG57965 AL834263 CAD38938 BC028051 AAH28051 BC050112 BC064613 AAH64613 BC152437 BC172253 AAI72253 BC172560 AAI72560 BQ716020 BU507256 CB990295 XM_005252051 XP_005252108 XM_006717143 XP_006717206 XM_011518784 XP_011517086 NM_005392 NP_005383 NM_024517
Function Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. {ECO:0000269|PubMed:20129925, ECO:0000269|PubMed:21167174, ECO:0000269|PubMed:21532585}.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:20129925}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.
Tissue Specificity Widely expressed, including in liver (at protein level). {ECO:0000269|PubMed:21532585}.

PHF2 CRISPR/Cas9 KO Plasmid (h) - sc-407404 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHF2 HDR Plasmid (h) - sc-407404-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHF2 Double Nickase Plasmid (h) - sc-407404-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHF2 Double Nickase Plasmid (h2) - sc-407404-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHF2 CRISPR Activation Plasmid (h) - sc-407404-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHF2 CRISPR Activation Plasmid (h2) - sc-407404-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHF2 Lentiviral Activation Particles (h) - sc-407404-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHF2 Lentiviral Activation Particles (h2) - sc-407404-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

PHF2 siRNA (h) - sc-92588 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PHF2 shRNA Plasmid (h) - sc-92588-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PHF2 shRNA (h) Lentiviral Particles - sc-92588-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN16724 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16724 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10548 from Sigma-Aldrich

Category miRNA

PHF2 siRNA (Human) - CRH3507 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PHF2(NM_005392.3) - SHR111160 from Creative biogene

Category siRNA
Species Reactivities Human

Human PHF2 siRNA - orb264009 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PHF2 shRNA Plasmid (Human) - CHH3507 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PHF2 miRNA 3'UTR clone - MiUTR1H-07856 from Creative biogene

Species Reactivities Human
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