| Gene Symbol | Fgd4 |
|---|---|
| Entrez Gene | 224014 |
| Alt Symbol | 9030023J02Rik, 9330209B17Rik, Frabp, ZFYVE6 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | FYVE, RhoGEF and PH domain containing 4 |
| Other Description | FYVE, RhoGEF and PH domain-containing protein 4|Fgd1-related F-actin-binding protein|actin filament-binding protein frabin |
| Swissprots | Q91ZT5 Q91ZT3 Q8BW60 A1L355 Q91ZT4 Q8BZI7 Q3UEB6 |
| Accessions | EDK97420 EDK97421 EDK97422 EDK97423 Q91ZT5 AF402611 AAL05631 AF402612 AAL05632 AF402613 AAL05633 AK028302 AK030390 BAC26939 AK033429 AK034504 BAC28733 AK042588 AK043656 AK054242 BAC35703 AK134961 BAE22357 AK149626 BAE28995 AK166883 AV137422 BB569027 BB617683 BC028644 BC129902 AAI29903 BC129903 AAI29904 BC145523 BQ175875 BQ445726 BQ831987 CA327140 CJ120679 CJ258048 CO045234 CO045914 XM_006522023 XP_006522086 XM_006522024 XP_006522087 XM_006522025 XP_006522088 XM_006522027 XP_006522090 XM_006522029 XP_006522092 XM_011245874 XP_011244176 XM_011245875 XP_011244177 XM_011245876 XP_011244178 XR_875778 NM_001301817 NP_001288746 NM_001301818 NP_001288747 NM_139232 NP_631978 NM_139233 NM_139234 |
| Function | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates MAPK8 (By similarity). Plays a role in regulating the actin cytoskeleton and cell shape. Promotes the formation of lamellipodia. {ECO:0000250, ECO:0000269|PubMed:10871857, ECO:0000269|PubMed:11527409}. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). {ECO:0000250}. |
| Tissue Specificity | Detected in thymus, lung, heart, skeletal muscle, small intestine, liver, kidney, spleen and testis. Expressed in all parts of the brain and in the spinal cord at embryonic, postnatal, and adult stages. Levels of expression are lower in postnatal and adult tissues than in embryonic tissues. {ECO:0000269|PubMed:11527409, ECO:0000269|PubMed:17564959}. |