| Gene Symbol |
KCNIP1
|
| Entrez Gene |
30820
|
| Alt Symbol |
KCHIP1, VABP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Kv channel interacting protein 1
|
| Other Description |
A-type potassium channel modulatory protein 1|Kv channel-interacting protein 1|potassium channel interacting protein 1|vesicle APC-binding protein
|
| Swissprots |
Q5U822 Q3YAD1 Q3YAD2 B7Z7B4 Q3YAD3 Q3YAD0 Q9NZI2
|
| Accessions |
EAW61470 EAW61471 Q9NZI2 AF199597 AAF33682 AI884645 AK074390 AK301775 BAH13550 AY170821 AAN77491 AY780424 AAV51968 BC035032 BC050375 AAH50375 BF514334 DC420716 DQ148476 AAZ77793 DQ148477 AAZ77794 DQ148478 AAZ77795 DQ148479 AAZ77796 XM_006714861 XP_006714924 XM_011534539 XP_011532841 NM_001034837 NP_001030009 NM_001034838 NP_001030010 NM_001278339 NP_001265268 NM_001278340 NP_001265269 NM_014592 NP_055407
|
| Function |
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface. {ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:11423117, ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:17187064}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:10676964}; Peripheral membrane protein {ECO:0000305|PubMed:10676964}. Cytoplasm {ECO:0000269|PubMed:10676964}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8R426}.
|
| Tissue Specificity |
Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus.
|