KCNIP1
| Gene Symbol | KCNIP1 |
|---|---|
| Entrez Gene | 30820 |
| Alt Symbol | KCHIP1, VABP |
| Species | Human |
| Gene Type | protein-coding |
| Description | Kv channel interacting protein 1 |
| Other Description | A-type potassium channel modulatory protein 1|Kv channel-interacting protein 1|potassium channel interacting protein 1|vesicle APC-binding protein |
| Swissprots | Q5U822 Q3YAD1 Q3YAD2 B7Z7B4 Q3YAD3 Q3YAD0 Q9NZI2 |
| Accessions | EAW61470 EAW61471 Q9NZI2 AF199597 AAF33682 AI884645 AK074390 AK301775 BAH13550 AY170821 AAN77491 AY780424 AAV51968 BC035032 BC050375 AAH50375 BF514334 DC420716 DQ148476 AAZ77793 DQ148477 AAZ77794 DQ148478 AAZ77795 DQ148479 AAZ77796 XM_006714861 XP_006714924 XM_011534539 XP_011532841 NM_001034837 NP_001030009 NM_001034838 NP_001030010 NM_001278339 NP_001265268 NM_001278340 NP_001265269 NM_014592 NP_055407 |
| Function | Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface. {ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:11423117, ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:17187064}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:10676964}; Peripheral membrane protein {ECO:0000305|PubMed:10676964}. Cytoplasm {ECO:0000269|PubMed:10676964}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8R426}. |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus. |
KChIP1 CRISPR/Cas9 KO Plasmid (h) - sc-406866 from Santa Cruz Biotechnology
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KChIP1 HDR Plasmid (h) - sc-406866-HDR from Santa Cruz Biotechnology
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KChIP1 Double Nickase Plasmid (h) - sc-406866-NIC from Santa Cruz Biotechnology
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KChIP1 Double Nickase Plasmid (h2) - sc-406866-NIC-2 from Santa Cruz Biotechnology
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KChIP1 CRISPR Activation Plasmid (h) - sc-406866-ACT from Santa Cruz Biotechnology
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KChIP1 CRISPR Activation Plasmid (h2) - sc-406866-ACT-2 from Santa Cruz Biotechnology
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KChIP1 Lentiviral Activation Particles (h) - sc-406866-LAC from Santa Cruz Biotechnology
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KChIP1 Lentiviral Activation Particles (h2) - sc-406866-LAC-2 from Santa Cruz Biotechnology
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KChIP1 siRNA (h) - sc-42400 from Santa Cruz Biotechnology
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KChIP1 shRNA Plasmid (h) - sc-42400-SH from Santa Cruz Biotechnology
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KChIP1 shRNA (h) Lentiviral Particles - sc-42400-V from Santa Cruz Biotechnology
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VABP RNAi - H00030820-R01 from Novus Biologicals
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VABP RNAi - H00030820-R03 from Novus Biologicals
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MISSION® esiRNA - EHU043931 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10949 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10949 from Sigma-Aldrich
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KCNIP1 siRNA (Human) - CRH9347 from Cohesion Biosciences
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VABP RNAi - H00030820-R02 from Novus Biologicals
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KCNIP1, siRNA - MBS8210523 from MyBioSource
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KCNIP1, siRNA - MBS8225450 from MyBioSource
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KCNIP1, siRNA - MBS8202188 from MyBioSource
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shRNA set against Human KCNIP1 (NM_014592.2) - SHH323131 from Creative biogene
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shRNA set against Human KCNIP1(NM_001034837.1) - SHL182514 from Creative biogene
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shRNA set against Human KCNIP1(NM_014592.2) - SHL182568 from Creative biogene
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shRNA set against Human KCNIP1(NM_001034838.1) - SHL182604 from Creative biogene
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