| Gene Symbol |
AS3MT
|
| Entrez Gene |
57412
|
| Alt Symbol |
CYT19
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
arsenite methyltransferase
|
| Other Description |
S-adenosyl-L-methionine:arsenic(III) methyltransferase|S-adenosylmethionine:arsenic (III) methyltransferase|arsenic (+3 oxidation state) methyltransferase|methylarsonite methyltransferase|methyltransferase cyt19
|
| Swissprots |
Q5PZ02 A6NP79 Q0VDK3 Q9HBK9 Q0VDK4
|
| Accessions |
AAV68045 EAW49668 EAW49669 Q9HBK9 AF226730 AAG09731 AK057833 AK225972 AK309737 AW139845 BC119637 AAI19638 BC119638 AAI19639 BC160057 AAI60057 DA368970 NM_020682 NP_065733
|
| Function |
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
![Western Blot: AS3MT Overexpression Lysate (Adult Normal) [NBP2-06623] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AS3MT.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8968_AS3MT%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06623-img0001.jpg)