Gene Symbol | AS3MT |
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Entrez Gene | 57412 |
Alt Symbol | CYT19 |
Species | Human |
Gene Type | protein-coding |
Description | arsenite methyltransferase |
Other Description | S-adenosyl-L-methionine:arsenic(III) methyltransferase|S-adenosylmethionine:arsenic (III) methyltransferase|arsenic (+3 oxidation state) methyltransferase|methylarsonite methyltransferase|methyltransferase cyt19 |
Swissprots | Q5PZ02 A6NP79 Q0VDK3 Q9HBK9 Q0VDK4 |
Accessions | AAV68045 EAW49668 EAW49669 Q9HBK9 AF226730 AAG09731 AK057833 AK225972 AK309737 AW139845 BC119637 AAI19638 BC119638 AAI19639 BC160057 AAI60057 DA368970 NM_020682 NP_065733 |
Function | Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
cyt19 CRISPR/Cas9 KO Plasmid (h) - sc-404196 from Santa Cruz Biotechnology
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cyt19 HDR Plasmid (h) - sc-404196-HDR from Santa Cruz Biotechnology
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cyt19 Double Nickase Plasmid (h) - sc-404196-NIC from Santa Cruz Biotechnology
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cyt19 Double Nickase Plasmid (h2) - sc-404196-NIC-2 from Santa Cruz Biotechnology
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cyt19 CRISPR Activation Plasmid (h) - sc-404196-ACT from Santa Cruz Biotechnology
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cyt19 CRISPR Activation Plasmid (h2) - sc-404196-ACT-2 from Santa Cruz Biotechnology
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cyt19 Lentiviral Activation Particles (h) - sc-404196-LAC from Santa Cruz Biotechnology
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cyt19 Lentiviral Activation Particles (h2) - sc-404196-LAC-2 from Santa Cruz Biotechnology
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cyt19 siRNA (h) - sc-60494 from Santa Cruz Biotechnology
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cyt19 shRNA Plasmid (h) - sc-60494-SH from Santa Cruz Biotechnology
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cyt19 shRNA (h) Lentiviral Particles - sc-60494-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN3557 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3557 from Sigma-Aldrich
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AS3MT siRNA (Human) - CRJ1438 from Cohesion Biosciences
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AS3MT - MBS8220804 from MyBioSource
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shRNA set against Human AS3MT (NM_020682.3) - SHH241046 from Creative biogene
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shRNA set against Human AS3MT(NM_020682.3) - SHG075824 from Creative biogene
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Human AS3MT siRNA - orb271939 from Biorbyt
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AS3MT shRNA Plasmid (Human) - CHJ1438 from Cohesion Biosciences
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AS3MT miRNA 3'UTR clone - MiUTR1H-00617 from Creative biogene
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