Gene Symbol | GNB4 |
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Entrez Gene | 59345 |
Alt Symbol | CMTD1F |
Species | Human |
Gene Type | protein-coding |
Description | guanine nucleotide binding protein (G protein), beta polypeptide 4 |
Other Description | G protein beta-4 subunit|guanine nucleotide-binding protein subunit beta-4|transducin beta chain 4 |
Swissprots | D3DNR8 Q9HAV0 B3KMH5 |
Accessions | CAE89866 EAW78403 EAW78404 Q9HAV0 AF300648 AAG18442 AK001890 BAG50987 AK022599 AK091332 AK290571 BAF83260 AK297174 BAG59667 AK310009 BC000873 AAH00873 HG496359 HQ447876 ADQ32360 XM_005247692 XP_005247749 XM_006713721 XP_006713784 XM_011513061 XP_011511363 NM_021629 NP_067642 |
Function | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. |
Tissue Specificity | Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Abundantly expressed in the axons and Schwann cells of peripheral nerves. {ECO:0000269|PubMed:11842130, ECO:0000269|PubMed:23434117}. |
Top Pathways | Dopaminergic synapse, Morphine addiction, Glutamatergic synapse, PI3K-Akt signaling pathway, GABAergic synapse |
G β 4 siRNA (h) - sc-41768 from Santa Cruz Biotechnology
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G β 4 shRNA Plasmid (h) - sc-41768-SH from Santa Cruz Biotechnology
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G β 4 shRNA (h) Lentiviral Particles - sc-41768-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU029901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9421 from Sigma-Aldrich
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GNB4 siRNA (Human) - CRJ1778 from Cohesion Biosciences
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GNB4 - MBS8239050 from MyBioSource
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shRNA set against Human GNB4 (NM_021629.3) - SHH304806 from Creative biogene
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shRNA set against Human GNB4(NM_021629.3) - SHH092225 from Creative biogene
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Human GNB4 siRNA - orb272279 from Biorbyt
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GNB4 shRNA Plasmid (Human) - CHJ1778 from Cohesion Biosciences
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GNB4 miRNA 3'UTR clone - MiUTR1H-04111 from Creative biogene
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