| Gene Symbol |
CENPF
|
| Entrez Gene |
1063
|
| Alt Symbol |
CENF, PRO1779, hcp-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
centromere protein F, 350/400kDa
|
| Other Description |
AH antigen|CENP-F kinetochore protein|cell-cycle-dependent 350K nuclear protein|centromere protein F|centromere protein F, 350/400kDa (mitosin)|centromere protein F, 350/400ka (mitosin)|kinetochore protein CENPF|mitosin
|
| Swissprots |
Q5VVM7 Q13171 P49454 Q13246
|
| Accessions |
CBX47616 EAW93350 P49454 AK307690 BC172232 AAI72232 BG680819 BQ774943 BU155312 BU662228 CD654009 U19769 AAA82889 U25725 AAA86889 U30872 AAA82935 XM_011509082 XP_011507384 XM_011509083 XP_011507385 NM_016343 NP_057427
|
| Function |
Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity ag
|
| Subcellular Location |
Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Relocalizes to the kinetochore/centromere (coronal surface of the outer plate) and the spindle during mitosis. Observed in nucleus during interphase but not in the nucleolus. At metaphase becomes localized to areas including kinetochore and mitotic apparatus as well as cytoplasm. By telophase, is concentrated within the intracellular bridge at either side of the mid-body.
|