UPF3A

Gene Symbol UPF3A
Entrez Gene 65110
Alt Symbol HUPF3A, RENT3A, UPF3
Species Human
Gene Type protein-coding
Description UPF3 regulator of nonsense transcripts homolog A (yeast)
Other Description hUpf3|nonsense mRNA reducing factor 3A|regulator of nonsense transcripts 3A|up-frameshift suppressor 3 homolog A
Swissprots Q5T8C9 A2A366 Q7Z6N3 Q5T8C3 Q86YK1 Q9BZI8 Q9H1J1
Accessions EAX09247 EAX09248 EAX09249 EAX09250 EAX09251 EAX09252 Q9H1J1 AF318575 AAG60690 AK001069 AK092586 AK097027 BAG53409 AK294545 BAG57751 AK302003 BAG63406 AY013250 AAG48510 BC008694 AAH08694 BC023569 AAH23569 BC047735 BQ008047 XM_005266200 XP_005266257 XM_005266201 XP_005266258 XM_005266202 XP_005266259 XM_006719991 XP_006720054 XM_011534844 XP_011533146 XM_011534845 XP_011533147 XM_011534846 XP_011533148 XM_011534847 XP_011533149 XM_011534848 XP_011533150 XM_011534849 XP_011533151 XM_011534850 XP_011533152 XR_941422 XR_941423 NM_023011 NP_075387 NM_080687 NP_542418
Function Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16601204}.
Subcellular Location Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.
Tissue Specificity Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed in fetal brain and spinal cord. {ECO:0000269|PubMed:11113196}.
Top Pathways RNA transport, mRNA surveillance pathway

Rent3a (C-17) - sc-20230 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Rent3a (H-17) - sc-23639 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Rent3a (H-17): sc-23639. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear and cytoplasmic staining of cells in seminiferous ducts and Leydig cells.

Rent3a (N-14) - sc-20228 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Rent3a (PL-B10) - sc-134427 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Rent3a (PL-B10): sc-134427. Western blot analysis of Rent3a expression in human Rent3a transfected (A) and non-transfected (B) 293T whole cell lysates.

Anti-UPF3A antibody - ab77423 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-UPF3A antibody (ab77423) at 1 µg/ml + Recombinant tagged human UPF3A fragment at 0.2 µgSecondaryGoat anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

Anti-UPF3A antibody - ab68777 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-UPF3A antibody (ab68777) at 1/500 dilutionLane 1 : UPF3A transfected 293T cell lysateLane 2 : Non transfected 293T cell lysate Lysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-UPF3A / UPF3 Antibody (aa233-245) - LS-C112886 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-UPF3A / UPF3 Antibody (aa359-408) - LS-C110598 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
UPF3A antibody LS-C110598 Western blot of Fetal Kidney lysate.

Anti-UPF3A / UPF3 Antibody (clone 2E2) - LS-C134097 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E2
Immunoperoxidase of monoclonal antibody to UPF3A on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]

UPF3A Antibody - NBP1-83136 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UPF3A Antibody - H00065110-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: UPF3A Antibody [H00065110-B01P] - Analysis of UPF3A expression in transfected 293T cell line by UPF3A polyclonal antibody. Lane 1: UPF3A transfected lysate(48.73 KDa). Lane 2: Non-transfected lysate.

UPF3A Antibody (2E2) - H00065110-M06 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E2
Western Blot: UPF3A Antibody (2E2) [H00065110-M06] - Analysis of UPF3A expression in transfected 293T cell line by UPF3A monoclonal antibody (M06), clone 2E2. Lane 1: UPF3A transfected lysatE (51 KDa). Lane 2: Non-transfected lysate.

UPF3A Antibody - H00065110-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: UPF3A Antibody [H00065110-B01] - analysis of UPF3A expression in transfected 293T cell line by UPF3A MaxPab polyclonal antibody (B01). Lane 1: UPF3A transfected lysate (51.00 KDa). Lane 2: Non-transfected lysate.

UPF3A Antibody - NBP1-57262 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: UPF3A Antibody [NBP1-57262] - Human kidney lysate, concentration 0.2-1 ug/ml.

UPF3A Antibody - NBP1-45245 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-UPF3A antibody produced in rabbit - SAB2104502 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-UPF3A, antibody produced in rabbit: <B>Cat. No. SAB2104502</B>: Immunoblotting analysis of UPF3A in fetal kidney tissue lysate with UPF3A anitbody at 1 μg/mL.

Anti-UPF3A antibody produced in mouse - SAB1400688 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Polyclonal Anti-UPF3A, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1400688</B>: Antibody concentration: 1.0 μg/mL using HeLa cells.

Monoclonal Anti-UPF3A antibody produced in mouse - SAB1402625 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E2
<B>Immunohistochemistry</B><BR/>Monoclonal Anti-UPF3A, antibody produced in mouse, clone 2E2, purified immunoglobulin: <B>Cat. No. SAB1402625</B>: Antibody concentration: 3 μg/mL using human small intestine tissue.

Anti-UPF3A antibody produced in rabbit - HPA018325 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-UPF3A: <B>Cat. No. HPA018325</B>: Immunohistochemical staining of human testis shows strong cytoplasmic and nuclear positivity in developing spermatocytes.

UPF3A antibody - middle region (ARP41000_P050) - ARP41000_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

UPF3A--RENT3A-Antibody-internal-region - AF3031a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Goat Anti-UPF3A / RENT3A Antibody (OAEB00760) - OAEB00760 from Aviva Systems Biology

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

UPF3A antibody - 70R-21173 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

UPF3A antibody - 70R-4731 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

UPF3A Antibody - abx116536 from Abbexa

Host Rabbit
Clonality Polyclonal
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