UPF3A

Gene Symbol UPF3A
Entrez Gene 65110
Alt Symbol HUPF3A, RENT3A, UPF3
Species Human
Gene Type protein-coding
Description UPF3 regulator of nonsense transcripts homolog A (yeast)
Other Description hUpf3|nonsense mRNA reducing factor 3A|regulator of nonsense transcripts 3A|up-frameshift suppressor 3 homolog A
Swissprots Q5T8C9 A2A366 Q7Z6N3 Q5T8C3 Q86YK1 Q9BZI8 Q9H1J1
Accessions EAX09247 EAX09248 EAX09249 EAX09250 EAX09251 EAX09252 Q9H1J1 AF318575 AAG60690 AK001069 AK092586 AK097027 BAG53409 AK294545 BAG57751 AK302003 BAG63406 AY013250 AAG48510 BC008694 AAH08694 BC023569 AAH23569 BC047735 BQ008047 XM_005266200 XP_005266257 XM_005266201 XP_005266258 XM_005266202 XP_005266259 XM_006719991 XP_006720054 XM_011534844 XP_011533146 XM_011534845 XP_011533147 XM_011534846 XP_011533148 XM_011534847 XP_011533149 XM_011534848 XP_011533150 XM_011534849 XP_011533151 XM_011534850 XP_011533152 XR_941422 XR_941423 NM_023011 NP_075387 NM_080687 NP_542418
Function Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation. {ECO:0000269|PubMed:11163187, ECO:0000269|PubMed:16601204}.
Subcellular Location Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.
Tissue Specificity Isoform 1 is strongly expressed in testis, uterus, muscle, fetal brain and spinal cord. Isoform 2 is strongly expressed in fetal brain and spinal cord. {ECO:0000269|PubMed:11113196}.
Top Pathways RNA transport, mRNA surveillance pathway

Rent3a CRISPR/Cas9 KO Plasmid (h) - sc-413076 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent3a HDR Plasmid (h) - sc-413076-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent3a Double Nickase Plasmid (h) - sc-413076-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent3a Double Nickase Plasmid (h2) - sc-413076-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent3a CRISPR Activation Plasmid (h) - sc-413076-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent3a CRISPR Activation Plasmid (h2) - sc-413076-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent3a Lentiviral Activation Particles (h) - sc-413076-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent3a Lentiviral Activation Particles (h2) - sc-413076-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent3a siRNA (h) - sc-38227 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rent3a shRNA Plasmid (h) - sc-38227-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rent3a shRNA (h) Lentiviral Particles - sc-38227-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UPF3A RNAi - H00065110-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

UPF3A RNAi - H00065110-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU114411 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22518 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22518 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07137 from Sigma-Aldrich

Category miRNA

UPF3A siRNA (Human) - CRJ2183 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UPF3A - MBS8212654 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human UPF3A siRNA - orb272684 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UPF3A shRNA Plasmid (Human) - CHJ2183 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UPF3A miRNA 3'UTR clone - MiUTR3H-07767 from Creative biogene

Species Reactivities Human

UPF3A miRNA 3'UTR clone - MiUTR3H-07768 from Creative biogene

Species Reactivities Human
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