| Gene Symbol |
HIST2H4A
|
| Entrez Gene |
8370
|
| Alt Symbol |
FO108, H4, H4/n, H4F2, H4FN, HIST2H4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone cluster 2, H4a
|
| Other Description |
H4 histone family, member N|H4 histone, family 2|histone 2, H4a|histone H4|histone IV, family 2
|
| Swissprots |
Q6NWP7 P62805 Q6DRA9 A2VCL0 Q6FGB8
|
| Accessions |
AAA52652 AAM83108 CAA24918 CAI12560 BC019846 BC093969 AAH93969 BC108260 BC112193 AAI12194 BC146448 AAI46449 BC153063 AAI53064 CR542172 CAG46969 NM_003548 NP_003539
|
| Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
|
| Subcellular Location |
Nucleus. Chromosome.
|
| Top Pathways |
Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism
|
![Western Blot: H4/n Overexpression Lysate (Adult Normal) [NBL1-11574] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for H4/n.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7229_H4-n%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11574-img0002.jpg)