Gene Symbol | HIST2H4A |
---|---|
Entrez Gene | 8370 |
Alt Symbol | FO108, H4, H4/n, H4F2, H4FN, HIST2H4 |
Species | Human |
Gene Type | protein-coding |
Description | histone cluster 2, H4a |
Other Description | H4 histone family, member N|H4 histone, family 2|histone 2, H4a|histone H4|histone IV, family 2 |
Swissprots | Q6NWP7 P62805 Q6DRA9 A2VCL0 Q6FGB8 |
Accessions | AAA52652 AAM83108 CAA24918 CAI12560 BC019846 BC093969 AAH93969 BC108260 BC112193 AAI12194 BC146448 AAI46449 BC153063 AAI53064 CR542172 CAG46969 NM_003548 NP_003539 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Subcellular Location | Nucleus. Chromosome. |
Top Pathways | Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism |