Gene Symbol | HIST2H4A |
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Entrez Gene | 8370 |
Alt Symbol | FO108, H4, H4/n, H4F2, H4FN, HIST2H4 |
Species | Human |
Gene Type | protein-coding |
Description | histone cluster 2, H4a |
Other Description | H4 histone family, member N|H4 histone, family 2|histone 2, H4a|histone H4|histone IV, family 2 |
Swissprots | Q6NWP7 P62805 Q6DRA9 A2VCL0 Q6FGB8 |
Accessions | AAA52652 AAM83108 CAA24918 CAI12560 BC019846 BC093969 AAH93969 BC108260 BC112193 AAI12194 BC146448 AAI46449 BC153063 AAI53064 CR542172 CAG46969 NM_003548 NP_003539 |
Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Subcellular Location | Nucleus. Chromosome. |
Top Pathways | Systemic lupus erythematosus, Viral carcinogenesis, Alcoholism |
Histone cluster 2 H4A CRISPR/Cas9 KO Plasmid (h) - sc-417544 from Santa Cruz Biotechnology
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Histone cluster 2 H4A HDR Plasmid (h) - sc-417544-HDR from Santa Cruz Biotechnology
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Histone cluster 2 H4A Double Nickase Plasmid (h) - sc-417544-NIC from Santa Cruz Biotechnology
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Histone cluster 2 H4A Double Nickase Plasmid (h2) - sc-417544-NIC-2 from Santa Cruz Biotechnology
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Histone cluster 2 H4A CRISPR Activation Plasmid (h) - sc-417544-ACT from Santa Cruz Biotechnology
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Histone cluster 2 H4A CRISPR Activation Plasmid (h2) - sc-417544-ACT-2 from Santa Cruz Biotechnology
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Histone cluster 2 H4A Lentiviral Activation Particles (h) - sc-417544-LAC from Santa Cruz Biotechnology
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Histone cluster 2 H4A Lentiviral Activation Particles (h2) - sc-417544-LAC-2 from Santa Cruz Biotechnology
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Histone cluster 2 H4A siRNA (h) - sc-105515 from Santa Cruz Biotechnology
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Histone cluster 2 H4A shRNA Plasmid (h) - sc-105515-SH from Santa Cruz Biotechnology
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Histone cluster 2 H4A shRNA (h) Lentiviral Particles - sc-105515-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10115 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10115 from Sigma-Aldrich
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HIST2H4A siRNA (Human) - CRH5490 from Cohesion Biosciences
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shRNA set against Human HIST2H4A (NM_003548.2) - SHH312977 from Creative biogene
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HIST2H4A shRNA Plasmid (Human) - CHH5490 from Cohesion Biosciences
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HIST2H4A miRNA 3'UTR clone - MiUTR3H-01073 from Creative biogene
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