| Gene Symbol | GLUD1 |
|---|---|
| Entrez Gene | 2746 |
| Alt Symbol | GDH, GDH1, GLUD |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutamate dehydrogenase 1 |
| Other Description | GDH 1|glutamate dehydrogenase (NAD(P)+)|glutamate dehydrogenase 1, mitochondrial |
| Swissprots | B3KV55 Q5TBU3 B4DGN5 P00367 |
| Accessions | AAD14931 CAA46994 CAA46996 CBX51390 EAW80300 EAW80301 EAW80302 EAW80303 EAW80304 P00367 AB209406 BAD92643 AF086070 AK094782 BAG52930 AK122685 BAG53667 AK222818 BAD96538 AK294685 BAG57846 AK297441 BAG59867 AK297456 BAG59880 AK303458 BAG64501 AK311722 BC040132 AAH40132 BC112946 AAI12947 DB460681 GU727646 ADU87647 J03248 AAA52523 M17697 AAA52524 M20867 AAA52526 M37154 AAA52525 X07674 CAA30521 X07769 CAA30598 XM_011539668 XP_011537970 XM_011539669 XP_011537971 NM_005271 NP_005262 |
| Function | Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). {ECO:0000250}. |
| Subcellular Location | Mitochondrion matrix. |
| Top Pathways | Nitrogen metabolism, Proximal tubule bicarbonate reclamation, Arginine and proline metabolism, Alanine, aspartate and glutamate metabolism, D-Glutamine and D-glutamate metabolism |