| Gene Symbol | EPB41 |
|---|---|
| Entrez Gene | 2035 |
| Alt Symbol | 4.1R, EL1, HE |
| Species | Human |
| Gene Type | protein-coding |
| Description | erythrocyte membrane protein band 4.1 |
| Other Description | EPB4.1|P4.1|band 4.1|elliptocytosis 1, RH-linked|erythrocyte surface protein band 4.1|protein 4.1 |
| Swissprots | Q5VXN8 Q5TB35 Q9Y578 Q8IXV9 D3DPN0 D3DPM9 Q14245 B1ALH9 Q9Y579 P11171 B1ALH8 P11176 |
| Accessions | AAD42223 EAX07662 EAX07663 EAX07664 EAX07665 EAX07666 EAX07667 EAX07668 P11171 AB209649 BAD92886 AF156225 AAD42222 AI076831 AI819579 AK299093 BAH12948 AK299736 BAH13113 AK307816 AK310655 AL833483 BC009063 BC039079 AAH39079 BC096104 AAH96104 BC096105 AAH96105 BC113841 AAI13842 BC114450 AAI14451 BE257308 BM465039 BM740451 BM997767 BU184161 DA480006 EU176300 ABW03751 J03796 AAA35793 M14993 AAA35795 M61733 AAA35797 R94392 XM_005245753 XP_005245810 XM_005245757 XP_005245814 XM_005245760 XP_005245817 XM_005245761 XP_005245818 XM_005245763 XP_005245820 XM_005245764 XP_005245821 XM_005245765 XP_005245822 XM_005245767 XP_005245824 XM_005245768 XP_005245825 XM_005245769 XP_005245826 XM_005245770 XP_005245827 XM_005245772 XP_005245829 XM_005245773 XP_005245830 XM_005245774 XP_005245831 XM_006710434 XP_006710497 XM_006710439 XP_006710502 XM_011540956 XP_011539258 XM_011540957 XP_011539259 XM_011540958 XP_011539260 XM_011540959 XP_011539261 XM_011540960 XP_011539262 XM_011540961 XP_011539263 XM_011540962 XP_011539264 XM_011540963 XP_011539265 XM_011540964 XP_011539266 XM_011540965 XP_011539267 XM_011540966 XP_011539268 NM_001166005 NP_001159477 NM_001166006 NP_001159478 NM_001166007 NP_001159479 NM_004437 NP_004428 NM_203342 NP_976217 NM_203343 NP_976218 |
| Function | Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. |
| Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12427749}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12427749}. Nucleus {ECO:0000269|PubMed:12427749}. |
| Top Pathways | Tight junction |