ADI1

Gene Symbol ADI1
Entrez Gene 55256
Alt Symbol APL1, ARD, Fe-ARD, HMFT1638, MTCBP1, Ni-ARD, SIPL, mtnD
Species Human
Gene Type protein-coding
Description acireductone dioxygenase 1
Other Description 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase|MT1-MMP cytoplasmic tail-binding protein-1|acireductone dioxygenase (Fe(2+)-requiring)|acireductone dioxygenase (Ni(2+)-requiring)|membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1|submergence induced protein 2|submergence-induced protein-like factor
Swissprots Q68CK2 Q6ZSF7 Q53QD3 Q9BV57 Q57YV7 Q96P85 Q9NV57 Q53HW3 Q7Z512 D6W4Y3
Accessions AAX82038 AAY24022 CAR81477 CAS91493 EAX01064 EAX01065 Q9BV57 AB073609 BAD38646 AB158319 BAD10866 AF087863 AAP97173 AF403478 AAL25800 AK001775 BAA91901 AK127473 BAC86996 AK222467 BAD96187 AK225278 BC001467 AAH01467 CB129674 DA559726 HQ448743 ADQ33221 XM_005264696 XP_005264753 NM_001306077 NP_001293006 NM_018269 NP_060739
Function Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. {ECO:0000255|HAMAP- Rule:MF_03154, ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:15938715}.
Subcellular Location Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.
Tissue Specificity Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney. {ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:14718544}.
Top Pathways Cysteine and methionine metabolism

ADI1-Over-expression-Lysate - LY13859a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag ADI1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ADI1 gene

ADI1 293T Cell Transient Overexpression Lysate(Denatured) - H00055256-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

ADI1 overexpression lysate - LY402662 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

ADI1 293 Cell Lysate - 402319 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

ADI1 Overexpression Lysate (Native) - NBL1-07340 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: ADI1 Overexpression Lysate (Adult Normal) [NBL1-07340] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ADI1.

ARD (h): 293T Lysate - sc-371918 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

ADI1 Over-expression Lysate Product - GWB-249273 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

ADI1 Overexpression Lysate (Denatured) - H00055256-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

ADI1 Overexpression Lysate (Denatured) - H00055256-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Panoply™ Human ADI1 Knockdown Stable Cell Line - CSC-DC000306 from Creative biogene

Category Cell Line
Species Human
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