| Gene Symbol |
ADI1
|
| Entrez Gene |
55256
|
| Alt Symbol |
APL1, ARD, Fe-ARD, HMFT1638, MTCBP1, Ni-ARD, SIPL, mtnD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
acireductone dioxygenase 1
|
| Other Description |
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase|MT1-MMP cytoplasmic tail-binding protein-1|acireductone dioxygenase (Fe(2+)-requiring)|acireductone dioxygenase (Ni(2+)-requiring)|membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1|submergence induced protein 2|submergence-induced protein-like factor
|
| Swissprots |
Q68CK2 Q6ZSF7 Q53QD3 Q9BV57 Q57YV7 Q96P85 Q9NV57 Q53HW3 Q7Z512 D6W4Y3
|
| Accessions |
AAX82038 AAY24022 CAR81477 CAS91493 EAX01064 EAX01065 Q9BV57 AB073609 BAD38646 AB158319 BAD10866 AF087863 AAP97173 AF403478 AAL25800 AK001775 BAA91901 AK127473 BAC86996 AK222467 BAD96187 AK225278 BC001467 AAH01467 CB129674 DA559726 HQ448743 ADQ33221 XM_005264696 XP_005264753 NM_001306077 NP_001293006 NM_018269 NP_060739
|
| Function |
Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. {ECO:0000255|HAMAP- Rule:MF_03154, ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:15938715}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.
|
| Tissue Specificity |
Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney. {ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:14718544}.
|
| Top Pathways |
Cysteine and methionine metabolism
|