ADI1

Gene Symbol ADI1
Entrez Gene 55256
Alt Symbol APL1, ARD, Fe-ARD, HMFT1638, MTCBP1, Ni-ARD, SIPL, mtnD
Species Human
Gene Type protein-coding
Description acireductone dioxygenase 1
Other Description 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase|MT1-MMP cytoplasmic tail-binding protein-1|acireductone dioxygenase (Fe(2+)-requiring)|acireductone dioxygenase (Ni(2+)-requiring)|membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1|submergence induced protein 2|submergence-induced protein-like factor
Swissprots Q68CK2 Q6ZSF7 Q53QD3 Q9BV57 Q57YV7 Q96P85 Q9NV57 Q53HW3 Q7Z512 D6W4Y3
Accessions AAX82038 AAY24022 CAR81477 CAS91493 EAX01064 EAX01065 Q9BV57 AB073609 BAD38646 AB158319 BAD10866 AF087863 AAP97173 AF403478 AAL25800 AK001775 BAA91901 AK127473 BAC86996 AK222467 BAD96187 AK225278 BC001467 AAH01467 CB129674 DA559726 HQ448743 ADQ33221 XM_005264696 XP_005264753 NM_001306077 NP_001293006 NM_018269 NP_060739
Function Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. {ECO:0000255|HAMAP- Rule:MF_03154, ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:15938715}.
Subcellular Location Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14.
Tissue Specificity Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney. {ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:14718544}.
Top Pathways Cysteine and methionine metabolism

ARD CRISPR/Cas9 KO Plasmid (h) - sc-412496 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARD HDR Plasmid (h) - sc-412496-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARD Double Nickase Plasmid (h) - sc-412496-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARD Double Nickase Plasmid (h2) - sc-412496-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARD CRISPR Activation Plasmid (h) - sc-412496-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARD CRISPR Activation Plasmid (h2) - sc-412496-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARD Lentiviral Activation Particles (h) - sc-412496-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARD Lentiviral Activation Particles (h2) - sc-412496-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ARD siRNA (h) - sc-72527 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ARD shRNA Plasmid (h) - sc-72527-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ARD shRNA (h) Lentiviral Particles - sc-72527-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU037621 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2881 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2881 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13070 from Sigma-Aldrich

Category miRNA

ADI1 siRNA (Human) - CRJ0601 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ADI1 - MBS8206374 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ADI1 (NM_018269.3) - SHH232434 from Creative biogene

Category siRNA
Species Reactivities Human

Human ADI1 siRNA - orb271102 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ADI1 shRNA Plasmid (Human) - CHJ0601 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ADI1 miRNA 3'UTR clone - MiUTR3H-12881 from Creative biogene

Species Reactivities Human
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