SFRP1
| Gene Symbol | SFRP1 |
|---|---|
| Entrez Gene | 6422 |
| Alt Symbol | FRP, FRP-1, FRP1, FrzA, SARP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | secreted frizzled-related protein 1 |
| Other Description | SARP-2|sFRP-1|secreted apoptosis-related protein 2 |
| Swissprots | O00546 Q8N474 O14779 |
| Accessions | AAK00753 AAK00754 EAW63260 EAW63261 Q8N474 AF001900 AAB61576 AF017987 AAB70793 AF056087 AAC12877 AK127331 BAC86934 AK293090 BAF85779 AL049995 BC004466 AAH04466 BC036503 AAH36503 BQ002015 CB956696 CN271890 DA571541 NM_003012 NP_003003 |
| Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. {ECO:0000250}. |
| Subcellular Location | Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding. |
| Tissue Specificity | Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. {ECO:0000269|PubMed:9391078}. |
| Top Pathways | Wnt signaling pathway |
SFRP1 Antibody - 4690 from Cell Signaling Technology
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SFRP1 (D5A7) Rabbit mAb - 3534 from Cell Signaling Technology
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FRP-1 (C-19) - sc-7425 from Santa Cruz Biotechnology
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FRP-1 (H-90) - sc-13939 from Santa Cruz Biotechnology
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FRP-1 (G-25) - sc-133595 from Santa Cruz Biotechnology
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Anti-SFRP1 antibody - ab4193 from Abcam
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Anti-SFRP1 antibody - ab66673 from Abcam
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Anti-SFRP1 antibody - ab137420 from Abcam
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Anti-SFRP1 antibody - ab110113 from Abcam
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Anti-SFRP1 antibody - ab84003 from Abcam
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Anti-SFRP1 antibody - ab94942 from Abcam
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Anti-SFRP1 antibody [EPR7003] - ab126613 from Abcam
![All lanes : Anti-SFRP1 antibody [EPR7003] (ab126613) at 1/1000 dilutionLane 1 : Human heart lysateLane 2 : MDA-MB-435 lysateLane 3 : A375 lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-rabbit HRP at 1/2000 dilution](http://www.bioprodhub.com/system/product_images/ab_products/2/sub_4/29119_SFRP1-Primary-antibodies-ab126613-1.jpg)
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Anti-SFRP1 Antibody (aa31-313) - LS-C10133 from LifeSpan Bioscience
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Anti-SFRP1 Antibody - LS-C91363 from LifeSpan Bioscience
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Anti-SFRP1 Antibody - LS-C150315 from LifeSpan Bioscience
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Anti-SFRP1 Antibody (C-Terminus) - LS-C30752 from LifeSpan Bioscience
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Anti-SFRP1 Antibody (N-Terminus, APC) - LS-C282680 from LifeSpan Bioscience
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Anti-SFRP1 Antibody (N-Terminus, Biotin) - LS-C282681 from LifeSpan Bioscience
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Anti-SFRP1 Antibody (N-Terminus, FITC) - LS-C282682 from LifeSpan Bioscience
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Anti-SFRP1 Antibody (N-Terminus, AP) - LS-C282683 from LifeSpan Bioscience
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Anti-SFRP1 Antibody (N-Terminus, Azide-free, HRP) - LS-C282684 from LifeSpan Bioscience
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Anti-SFRP1 Antibody (N-Terminus, PE) - LS-C282688 from LifeSpan Bioscience
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Anti-SFRP1 Antibody (aa32-314, Biotin) - LS-C298495 from LifeSpan Bioscience
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Anti-SFRP1 Antibody (aa8-153, Biotin) - LS-C298496 from LifeSpan Bioscience
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Anti-SFRP1 Antibody (aa8-153, FITC) - LS-C305150 from LifeSpan Bioscience
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