SFRP1

Gene Symbol	SFRP1
Entrez Gene	6422
Alt Symbol	FRP, FRP-1, FRP1, FrzA, SARP2
Species	Human
Gene Type	protein-coding
Description	secreted frizzled-related protein 1
Other Description	SARP-2|sFRP-1|secreted apoptosis-related protein 2
Swissprots	O00546 Q8N474 O14779
Accessions	AAK00753 AAK00754 EAW63260 EAW63261 Q8N474 AF001900 AAB61576 AF017987 AAB70793 AF056087 AAC12877 AK127331 BAC86934 AK293090 BAF85779 AL049995 BC004466 AAH04466 BC036503 AAH36503 BQ002015 CB956696 CN271890 DA571541 NM_003012 NP_003003
Function	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. {ECO:0000250}.
Subcellular Location	Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding.
Tissue Specificity	Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. {ECO:0000269|PubMed:9391078}.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SFRP1 ELISA Kit (Sandwich ELISA) - LS-F6852 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 31.25-2000 pg/ml

Mouse SFRP1 ELISA Kit (Sandwich ELISA) - LS-F6732 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 13.3 pg/ml Range 31.25-2000 pg/ml

Rat SFRP1 ELISA Kit (Sandwich ELISA) - LS-F7706 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 31.25-2000 pg/ml

Follistatin Like Protein 1 (FSTL1), Human, ELISA Kit - CSB-E13516h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Follistatin Like Protein 1 (FSTL1), Human, ELISA Kit - SEJ085Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 14.2pg/mL Range 31.2-2,000pg/mL

Secreted Frizzled-Related Protein 1 (SFRP1), Human, ELISA Kit - CSB-E15074h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.78 pg/ml Range 3.12 pg/ml -200 pg/ml

Secreted frizzled-related protein 1, SFRP1, Human, ELISA Kit - E1165h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.78-50 ng/mL

Custom Human sFRP-1 ELISA - ELH-SFRP1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Secreted Frizzled Related Protein, ELISA Kit - MBS7206661 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Secreted Frizzled Related Protein, ELISA Kit - MBS7208467 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Secreted Frizzled Related Protein, ELISA Kit - MBS7235353 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Secreted Frizzled Related Protein, ELISA Kit - MBS727078 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Secreted Frizzled Related Protein, ELISA Kit - MBS7232566 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Secreted Frizzled Related Protein, ELISA Kit - MBS7252537 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Secreted Frizzled Related Protein, ELISA Kit - MBS7209798 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Secreted Frizzled Related Protein, ELISA Kit - MBS7251271 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Secreted Frizzled Related Protein, ELISA Kit - MBS7205540 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Secreted Frizzled Related Protein, ELISA Kit - MBS7235749 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Secreted Frizzled Related Protein, ELISA Kit - MBS7245544 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Secreted Frizzled Related Protein 1, ELISA Kit - MBS733935 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Secreted Frizzled Related Protein 1 (SFRP1), ELISA Kit - MBS9307548 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Secreted Frizzled Related Protein 1 (SFRP1), ELISA Kit - MBS9307370 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Secreted Frizzled-Related Protein 1, ELISA Kit - MBS034064 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Secreted Frizzled-Related Protein 1, ELISA Kit - MBS040470 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Secreted Frizzled-Related Protein 1, ELISA Kit - MBS038168 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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