| Gene Symbol |
SFRP1
|
| Entrez Gene |
6422
|
| Alt Symbol |
FRP, FRP-1, FRP1, FrzA, SARP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
secreted frizzled-related protein 1
|
| Other Description |
SARP-2|sFRP-1|secreted apoptosis-related protein 2
|
| Swissprots |
O00546 Q8N474 O14779
|
| Accessions |
AAK00753 AAK00754 EAW63260 EAW63261 Q8N474 AF001900 AAB61576 AF017987 AAB70793 AF056087 AAC12877 AK127331 BAC86934 AK293090 BAF85779 AL049995 BC004466 AAH04466 BC036503 AAH36503 BQ002015 CB956696 CN271890 DA571541 NM_003012 NP_003003
|
| Function |
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. {ECO:0000250}.
|
| Subcellular Location |
Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding.
|
| Tissue Specificity |
Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. {ECO:0000269|PubMed:9391078}.
|
| Top Pathways |
Wnt signaling pathway
|
![Western Blot: SFRP1 Overexpression Lysate (Adult Normal) [NBL1-15883] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SFRP1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4518_SFRP1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15883-img0002.jpg)