SFRP1

Gene Symbol	SFRP1
Entrez Gene	6422
Alt Symbol	FRP, FRP-1, FRP1, FrzA, SARP2
Species	Human
Gene Type	protein-coding
Description	secreted frizzled-related protein 1
Other Description	SARP-2|sFRP-1|secreted apoptosis-related protein 2
Swissprots	O00546 Q8N474 O14779
Accessions	AAK00753 AAK00754 EAW63260 EAW63261 Q8N474 AF001900 AAB61576 AF017987 AAB70793 AF056087 AAC12877 AK127331 BAC86934 AK293090 BAF85779 AL049995 BC004466 AAH04466 BC036503 AAH36503 BQ002015 CB956696 CN271890 DA571541 NM_003012 NP_003003
Function	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. {ECO:0000250}.
Subcellular Location	Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding.
Tissue Specificity	Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. {ECO:0000269|PubMed:9391078}.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SFRP1 ORF Clone(NM_003012.4) - CDCL175215 from Creative Biomart Species Human Accession NM_003012.4

human SFRP1 ORF clone - CDCH079244 from Creative Biomart Species Human Accession NM_003012

human SFRP1 ORF clone - CDCH079245 from Creative Biomart Species Human Accession NM_003012

human SFRP1 ORF clone - CDCH079246 from Creative Biomart Species Human Accession NM_003012

human SFRP1 ORF clone - CDCH079247 from Creative Biomart Species Human Accession NM_003012

human SFRP1 ORF clone - CDCH079248 from Creative Biomart Species Human Accession NM_003012

human SFRP1 ORF clone - CDCH079249 from Creative Biomart Species Human Accession NM_003012

Human SFRP1 Gene ORF cDNA clone in cloning vector - HG10680-U from Sino Biological Species Human

Human SFRP1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10680-ACR from Sino Biological Species Human

Human SFRP1 Gene ORF cDNA clone expression plasmid - HG10680-UT from Sino Biological Species Human

Human SFRP1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10680-NH from Sino Biological Species Human

Human SFRP1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10680-NF from Sino Biological Species Human

Human SFRP1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10680-NM from Sino Biological Species Human

Human SFRP1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10680-CY from Sino Biological Species Human

Human SFRP1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10680-CF from Sino Biological Species Human

Human SFRP1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10680-CM from Sino Biological Species Human

Human SFRP1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10680-NY from Sino Biological Species Human

Human SFRP1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10680-CH from Sino Biological Species Human

Human SFRP1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10680-ACG from Sino Biological Species Human

human SFRP1 ORF clone (NM_003012.4) - CDCH079244 from Creative biogene Species Human

Human FSTL1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10924-ACG from Sino Biological Species Human

Human FSTL1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10924-ACR from Sino Biological Species Human

Human FSTL1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10924-CF from Sino Biological Species Human

Human FSTL1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10924-CM from Sino Biological Species Human

Human FSTL1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10924-CY from Sino Biological Species Human

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