SFRP1

Gene Symbol	SFRP1
Entrez Gene	6422
Alt Symbol	FRP, FRP-1, FRP1, FrzA, SARP2
Species	Human
Gene Type	protein-coding
Description	secreted frizzled-related protein 1
Other Description	SARP-2|sFRP-1|secreted apoptosis-related protein 2
Swissprots	O00546 Q8N474 O14779
Accessions	AAK00753 AAK00754 EAW63260 EAW63261 Q8N474 AF001900 AAB61576 AF017987 AAB70793 AF056087 AAC12877 AK127331 BAC86934 AK293090 BAF85779 AL049995 BC004466 AAH04466 BC036503 AAH36503 BQ002015 CB956696 CN271890 DA571541 NM_003012 NP_003003
Function	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. {ECO:0000250}.
Subcellular Location	Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding.
Tissue Specificity	Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. {ECO:0000269|PubMed:9391078}.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SFRP1 full length protein - ab174080 from Abcam Category Protein Prices $372.00 Sizes 50 µg Source HEK 293 cells Species Human

Active human SFRP1 full length protein - ab64445 from Abcam Category Protein Prices $110.00, $239.00 Sizes 5 µg, 20 µg Source HeLa cells Species Human

Human SFRP1 full length protein - ab152673 from Abcam Category Protein Source Wheat germ Species Human

Human SFRP1 peptide - ab101296 from Abcam Category Peptide

SFRP1 Antibody Blocking Peptide - LS-E10647 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SFRP1 Antibody Blocking Peptide - LS-E26847 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SFRP1 Antibody Blocking Peptide - LS-E26891 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SFRP1 Antibody Blocking Peptide - LS-E9909 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

sFRP-1 Recombinant Protein - H00006422-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

SFRP1-Antibody-N-term-Blocking-Peptide - BP9037a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SFRP1 Recombinant Protein (Active) - GTX48140-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source Human Species Human

FSTL1 blocking peptide - GTX11805-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Bovine

Recombinant Human sFRP-1, CF - 5396-SF-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser32-Lys314

Recombinant Human sFRP-1 (Histidine-tagged) - 1384-SF-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser32-Lys314 with a C-terminal 6-His tag

Recombinant Human sFRP-1 (Histidine-tagged), CF - 1384-SF-025/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser32-Lys314 with a C-terminal 6-His tag

Human SFRP1 Protein (OPSA11773) - OPSA11773 from Aviva Systems Biology Category Protein Prices $440.00 Sizes 20 µg Species Human

FSTL1 protein (His tag) - 80R-3008 from Fitzgerald Category Protein Prices $275.00 Sizes 20 µg Source E.coli

SFRP1 Blocking Peptide - 33R-3825 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

sFRP1 protein - 30R-AS046 from Fitzgerald Category Protein Prices $225.00 Sizes 20 µg

SFRP1 Peptide - AC21-1678-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SFRP1 - H00006422-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SFRP1 - P5999 from Acris Antibodies Category Protein Prices $580.00 Sizes 20 µg Species Human

sFRP-1, Recombinant Human - 213-10115-1 from RayBiotech Category Protein Prices $75.00 Sizes 1 µg Source HeLa cells Species Human

Recombinant Human sFRP-1 - 213-10115-2 from RayBiotech Category Protein Prices $190.00 Sizes 2 µg Source HeLa cells Species Human

SFRP1 Peptide - 42-478P from ProSci Category Peptide Species Human

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