| Gene Symbol |
SPRR1B
|
| Entrez Gene |
6699
|
| Alt Symbol |
CORNIFIN, GADD33, SPRR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
small proline-rich protein 1B
|
| Other Description |
14.9 kDa pancornulin|SPR-IB|cornifin B|cornifin-B|small proline-rich protein IB
|
| Swissprots |
B2R5H7 P22530 P22529 Q5T524 P22528
|
| Accessions |
AAA36643 AAV40826 EAW53351 P22528 AK312191 BAG35124 BC056240 AAH56240 BC156326 AAI56327 BC157076 AAI57077 CK300778 DQ323996 ABC88598 M19888 AAA36636 M21300 AAA36637 M21301 AAA36638 NM_003125 NP_003116
|
| Function |
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.
|
