Gene Symbol | SPRR1B |
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Entrez Gene | 6699 |
Alt Symbol | CORNIFIN, GADD33, SPRR1 |
Species | Human |
Gene Type | protein-coding |
Description | small proline-rich protein 1B |
Other Description | 14.9 kDa pancornulin|SPR-IB|cornifin B|cornifin-B|small proline-rich protein IB |
Swissprots | B2R5H7 P22530 P22529 Q5T524 P22528 |
Accessions | AAA36643 AAV40826 EAW53351 P22528 AK312191 BAG35124 BC056240 AAH56240 BC156326 AAI56327 BC157076 AAI57077 CK300778 DQ323996 ABC88598 M19888 AAA36636 M21300 AAA36637 M21301 AAA36638 NM_003125 NP_003116 |
Function | Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea. |
SPRR1B CRISPR/Cas9 KO Plasmid (h) - sc-417932 from Santa Cruz Biotechnology
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SPRR1B HDR Plasmid (h) - sc-417932-HDR from Santa Cruz Biotechnology
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SPRR1B Double Nickase Plasmid (h) - sc-417932-NIC from Santa Cruz Biotechnology
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SPRR1B Double Nickase Plasmid (h2) - sc-417932-NIC-2 from Santa Cruz Biotechnology
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SPRR1B CRISPR Activation Plasmid (h) - sc-417932-ACT from Santa Cruz Biotechnology
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SPRR1B CRISPR Activation Plasmid (h2) - sc-417932-ACT-2 from Santa Cruz Biotechnology
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SPRR1B Lentiviral Activation Particles (h) - sc-417932-LAC from Santa Cruz Biotechnology
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SPRR1B Lentiviral Activation Particles (h2) - sc-417932-LAC-2 from Santa Cruz Biotechnology
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SPRR1B siRNA (h) - sc-88444 from Santa Cruz Biotechnology
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SPRR1B shRNA Plasmid (h) - sc-88444-SH from Santa Cruz Biotechnology
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SPRR1B shRNA (h) Lentiviral Particles - sc-88444-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU108941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20519 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20519 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02113 from Sigma-Aldrich
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SPRR1B siRNA (Human) - CRH4569 from Cohesion Biosciences
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SPRR1B - MBS8214622 from MyBioSource
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shRNA set against Human SPRR1B (NM_003125.2) - SHH417240 from Creative biogene
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shRNA set against Human SPRR1B(NM_003125.2) - SHL030774 from Creative biogene
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Human SPRR1B siRNA - orb265071 from Biorbyt
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SPRR1B shRNA Plasmid (Human) - CHH4569 from Cohesion Biosciences
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SPRR1B miRNA 3'UTR clone - MiUTR1H-09870 from Creative biogene
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