| Gene Symbol | CADPS2 |
|---|---|
| Entrez Gene | 93664 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | Ca++-dependent secretion activator 2 |
| Other Description | CAPS-2|Ca2+-dependent activator protein for secretion 2|calcium-dependent activator protein for secretion 2|calcium-dependent secretion activator 2 |
| Swissprots | Q8N7M4 Q86UW7 Q8IZW9 Q9HCI1 Q7Z5T7 B7ZM56 Q9H6P4 Q9NWK8 A4D0X3 Q658Q2 |
| Accessions | CCQ43023 CCQ43024 EAL24339 EAW83571 EAW83572 EAW83573 EAW83574 EAW83575 EAW83576 Q86UW7 AB046811 BAB13417 AF401638 AAN38707 AK000768 BAA91372 AK025672 BAB15210 AK054853 BAG51434 AK126518 BAG54341 AL833058 CAH56288 AY264289 AAP22132 BC054339 AAH54339 BC136601 AAI36602 BC144278 AAI44279 BC144279 AAI44280 BX110721 DA118516 DA248542 DA323097 KJ534798 AHW56438 KJ534799 AHW56439 KJ534800 AHW56440 KJ534801 AHW56441 KJ534802 AHW56442 KJ534803 AHW56443 KJ534804 AHW56444 KJ534805 AHW56445 KJ535060 AHW56699 XM_005250695 XP_005250752 XM_005250696 XP_005250753 XM_005250697 XP_005250754 XM_005250698 XP_005250755 XM_005250699 XP_005250756 XM_005250700 XP_005250757 XM_005250701 XP_005250758 XM_005250702 XP_005250759 XM_005250703 XP_005250760 XM_005250704 XP_005250761 XM_005250705 XP_005250762 XM_005250706 XP_005250763 XM_005250707 XP_005250764 XM_005250708 XP_005250765 XM_011516695 XP_011514997 XM_011516696 XP_011514998 XM_011516697 XP_011514999 NM_001009571 NP_001009571 NM_001167940 NP_001161412 NM_017954 NP_060424 |
| Function | Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)- dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasmic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell junction, synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Probably localizes to different vesicles compared to CADPS. Enriched on vesicular structures in the parallel fiber terminal of granule cells that are distinct from synaptic vesicles. |
| Tissue Specificity | Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen. {ECO:0000269|PubMed:12659812}. |
CAPS-2 CRISPR/Cas9 KO Plasmid (h) - sc-407499 from Santa Cruz Biotechnology
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CAPS-2 HDR Plasmid (h) - sc-407499-HDR from Santa Cruz Biotechnology
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CAPS-2 Double Nickase Plasmid (h) - sc-407499-NIC from Santa Cruz Biotechnology
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CAPS-2 Double Nickase Plasmid (h2) - sc-407499-NIC-2 from Santa Cruz Biotechnology
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CAPS-2 CRISPR Activation Plasmid (h) - sc-407499-ACT from Santa Cruz Biotechnology
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CAPS-2 CRISPR Activation Plasmid (h2) - sc-407499-ACT-2 from Santa Cruz Biotechnology
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CAPS-2 Lentiviral Activation Particles (h) - sc-407499-LAC from Santa Cruz Biotechnology
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CAPS-2 Lentiviral Activation Particles (h2) - sc-407499-LAC-2 from Santa Cruz Biotechnology
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CAPS-2 siRNA (h) - sc-62078 from Santa Cruz Biotechnology
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CAPS-2 shRNA Plasmid (h) - sc-62078-SH from Santa Cruz Biotechnology
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CAPS-2 shRNA (h) Lentiviral Particles - sc-62078-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU133361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5287 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5287 from Sigma-Aldrich
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CADPS2 siRNA (Human) - CRJ4227 from Cohesion Biosciences
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CADPS2 - MBS827771 from MyBioSource
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shRNA set against Human CADPS2 (NM_017954.10) - SHH253645 from Creative biogene
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Human CADPS2 siRNA - orb274728 from Biorbyt
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CADPS2 shRNA Plasmid (Human) - CHJ4227 from Cohesion Biosciences
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CADPS2 miRNA 3'UTR clone - MiUTR3H-10934 from Creative biogene
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CADPS2 miRNA 3'UTR clone - MiUTR3H-10935 from Creative biogene
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