FUS

Gene Symbol FUS
Entrez Gene 2521
Alt Symbol ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS
Species Human
Gene Type protein-coding
Description FUS RNA binding protein
Other Description 75 kDa DNA-pairing protein|RNA-binding protein FUS|fus-like protein|fused in sarcoma|fusion gene in myxoid liposarcoma|heterogeneous nuclear ribonucleoprotein P2|oncogene FUS|oncogene TLS|translocated in liposarcoma protein
Swissprots Q9H4A8 P35637
Accessions AAC35284 AAC35285 CAD82835 EAW52150 EAW52151 EAW52152 P35637 AB208902 BAD92139 AI333366 AK098774 AK130774 AK290936 BAF83625 AK299129 BAG61182 AK301110 BAG62709 AW408771 AW514140 BC000402 AAH00402 BC002459 AAH02459 BC026062 AAH26062 BC051293 BT007131 AAP35795 BX423519 CR456747 CAG33028 DA541747 DC361263 DQ891705 ABM82631 DQ894882 ABM85808 GU933437 R07006 S62140 AAB27102 U00942 U36561 AAA79948 X71428 CAA50559 XM_005255233 XP_005255290 XM_011545781 XP_011544083 XM_011545782 XP_011544084 NM_001170634 NP_001164105 NM_001170937 NP_001164408 NM_004960 NP_004951 NR_028388 NM_001010850
Function Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
Subcellular Location Nucleus {ECO:0000269|PubMed:19251627, ECO:0000269|PubMed:19251628}.
Tissue Specificity Ubiquitous.
Top Pathways Transcriptional misregulation in cancer

FUS/TLS Antibody - 4885 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using FUS/TLS Antibody.

FUS/TLS (H-6) - sc-373698 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FUS/TLS (H-6): sc-373698. Immunofluorescence staining of formalin-fixed HeLa cells showing nuclear localization. Kindly provided by Yang Xiang, Ph.D., Division of Newborn Medicine, Boston Childrens Hospital, Cell Biology Department, Harvard Medical School.

FUS/TLS (D-8) - sc-373888 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FUS/TLS (D-8): sc-373888. Western blot analysis of FUS/TLS expression in THP-1 whole cell lysate.

FUS/TLS (H-76) - sc-25540 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FUS/TLS (H-76): sc-25540. Western blot analysis of FUS/TLS expression in THP-1 whole cell lysate.

FUS/TLS (4H11) - sc-47711 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FUS/TLS (4H11): sc-47711. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

FUS/TLS (N-18) - sc-8530 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FUS/TLS (N-18): sc-8530. Western blot analysis of FUS/TLS expression in HL-60 (A), K-562 (B), NAMALWA (C) and THP-1 (D) whole cell lysates.

FUS/TLS (15) - sc-135911 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
FUS/TLS (15): sc-135911. Western blot analysis of FUS/TLS expression in Jurkat whole cell lysate.

Anti-TLS/FUS antibody - ab23439 from Abcam

Prices $392.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TLS/FUS antibody (ab23439) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Nuclear LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Nuclear Lysate (ab14844)Lysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TLS/FUS antibody - ab93644 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TLS/FUS antibody (ab93644) at 1/200 dilutionLane 1 : PRF5 cell lysateLane 2 : HeLa cell lysateLane 3 : SMMC-7721 cell lysateLane 4 : QGY-7703 cell lysate

Anti-TLS/FUS antibody [CL0190] - ab154141 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone CL0190
Immunohistochemical analysis of Human kidney tissue labeling TLS/FUS with ab154141 at 1/2500 dilution.

Anti-TLS/FUS antibody [EPR5812] - ab124923 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5812
All lanes : Anti-TLS/FUS antibody [EPR5812] (ab124923) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : Human fetal brain lysateLane 3 : Caco 2 cell lysateLane 4 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-TLS/FUS antibody [EPR5813] - ab133571 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5813
Anti-TLS/FUS antibody [EPR5813] (ab133571) at 1/1000 dilution (unpurified) + HL-60 cell lysate at 10 µgSecondaryPeroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Anti-FUS / TLS Antibody - LS-C48694 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FUS / TLS Antibody (aa200-250) - LS-C66382 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FUS / TLS Antibody (C-Terminus) - LS-C66384 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FUS / TLS Antibody (aa1-50) - LS-C66386 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FUS / TLS Antibody (C-Terminus) - LS-C137093 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FUS / TLS Antibody (aa1-150, Biotin) - LS-C143552 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FUS / TLS Antibody (aa1-150, DY650) - LS-C143553 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FUS / TLS Antibody (aa1-150, DY488) - LS-C143554 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FUS / TLS Antibody (Internal, clone EPR5812) - LS-C138845 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5812
IHC of paraffin-embedded human kidney tissue using anti-FUS antibody.

Anti-FUS / TLS Antibody (aa1-150, HRP) - LS-C143555 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FUS / TLS Antibody (Internal, clone EPR5813) - LS-C138904 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone [EPR5813]
IHC of paraffin-embedded human breast tissue using anti-FUS antibody.

Anti-FUS / TLS Antibody (aa1-150, DY550) - LS-C143556 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FUS / TLS Antibody (Internal) - LS-C153400 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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