| Gene Symbol |
FUS
|
| Entrez Gene |
2521
|
| Alt Symbol |
ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FUS RNA binding protein
|
| Other Description |
75 kDa DNA-pairing protein|RNA-binding protein FUS|fus-like protein|fused in sarcoma|fusion gene in myxoid liposarcoma|heterogeneous nuclear ribonucleoprotein P2|oncogene FUS|oncogene TLS|translocated in liposarcoma protein
|
| Swissprots |
Q9H4A8 P35637
|
| Accessions |
AAC35284 AAC35285 CAD82835 EAW52150 EAW52151 EAW52152 P35637 AB208902 BAD92139 AI333366 AK098774 AK130774 AK290936 BAF83625 AK299129 BAG61182 AK301110 BAG62709 AW408771 AW514140 BC000402 AAH00402 BC002459 AAH02459 BC026062 AAH26062 BC051293 BT007131 AAP35795 BX423519 CR456747 CAG33028 DA541747 DC361263 DQ891705 ABM82631 DQ894882 ABM85808 GU933437 R07006 S62140 AAB27102 U00942 U36561 AAA79948 X71428 CAA50559 XM_005255233 XP_005255290 XM_011545781 XP_011544083 XM_011545782 XP_011544084 NM_001170634 NP_001164105 NM_001170937 NP_001164408 NM_004960 NP_004951 NR_028388 NM_001010850
|
| Function |
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19251627, ECO:0000269|PubMed:19251628}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Transcriptional misregulation in cancer
|
![Western Blot: FUS Overexpression Lysate (Adult Normal) [NBL1-10861] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FUS.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/8538_FUS%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-10861-img0002.jpg)