PLK1

Gene Symbol	PLK1
Entrez Gene	5347
Alt Symbol	PLK, STPK13
Species	Human
Gene Type	protein-coding
Description	polo-like kinase 1
Other Description	PLK-1|cell cycle regulated protein kinase|polo (Drosophia)-like kinase|polo like kinase|serine/threonine-protein kinase 13|serine/threonine-protein kinase PLK1
Swissprots	P53350 Q99746 Q15153
Accessions	AAB36946 CAA62260 CAS92530 CAT02195 EAW55803 EAW55804 EAW55805 EAW55806 P53350 AB084459 BAD93352 AB209179 BAD92416 AK303263 BAG64345 AK308276 AK313227 BAG36038 BC002369 AAH02369 BC003002 AAH03002 BC014846 AAH14846 DQ891045 ABM81971 DQ894224 ABM85150 L19559 AAA36659 U01038 AAA56634 X73458 CAA51837 X75932 CAA53536 NM_005030 NP_005021
Function	Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an i
Subcellular Location	Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGOL1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization. Localizes onto the central spindle by phosphorylating and docking at midzone proteins KIF20A/MKLP2 and PRC1. Colocalizes with FRY to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle.
Tissue Specificity	Placenta and colon.
Top Pathways	Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PLK1-Over-expression-Lysate - LY11701a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PLK1 293T Cell Transient Overexpression Lysate(Denatured) - H00005347-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PLK1 overexpression lysate - LY417592 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PLK1 293 Cell Lysate - 408233 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Drosophila

PLK1 Overexpression Lysate (Native) - NBL1-14515 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Plk (h): 293 Lysate - sc-111085 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Plk (h2): 293T Lysate - sc-170528 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

PLK1 Over-expression Lysate Product - GWB-2883ED from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human PLK1 / PLK-1 Insect Cell Lysate (WB positive control) - 10676-H07BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

PLK1 Overexpression Lysate (Denatured) - H00005347-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

PLK1 Overexpression Lysate (Denatured) - H00005347-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human PLK1 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb174933 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human PLK1 Knockdown Stable Cell Line - CSC-DC011962 from Creative biogene Category Cell Line Species Human

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