Recombinant Human IL-27, CF

• Supplier: R&D Systems
• Catalog: 2526-IL-010/CF
• Category: Protein
• Nature: Recombinant
• Source: Mouse myeloma cell line, NS0-derived
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• SwissProt/Accession: Q14213.2 (EBI3) & AAM34498 (p28)
• Gene: IL27

Product References

IL-27, a cytokine, and IFN-lambda1, a type III IFN, are coordinated to regulate - IL-27, a cytokine, and IFN-lambda1, a type III IFN, are coordinated to regulate

Cao Y, Zhang R, Zhang W, Zhu C, Yu Y, Song Y, Wang Q, Bai L, Liu Y, Wu K, Wu J. J Immunol. 2014 Jan 15;192(2):691-703.

Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in - Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in

Tzeng TT, Tsay HJ, Chang L, Hsu CL, Lai TH, Huang FL, Shiao YJ. J Biomed Sci. 2013 Dec 6;20:90.

IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production - IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production

Kachroo P, Lee MH, Zhang L, Baratelli F, Lee G, Srivastava MK, Wang G, Walser TC, Krysan K, Sharma S, Dubinett SM, Lee JM. J Exp Clin Cancer Res. 2013 Nov 25;32:97.

Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein - Influenza A virus induces interleukin-27 through cyclooxygenase-2 and protein

Liu L, Cao Z, Chen J, Li R, Cao Y, Zhu C, Wu K, Wu J, Liu F, Zhu Y. J Biol Chem. 2012 Apr 6;287(15):11899-910.

Human TCRgammadelta+ T cells represent a novel target for IL-27 activity. - Human TCRgammadelta+ T cells represent a novel target for IL-27 activity.

Morandi F, Prigione I, Airoldi I. Eur J Immunol. 2012 Jun;42(6):1547-52.

Complementary IL-23 and IL-27 anti-tumor activities cause strong inhibition of - Complementary IL-23 and IL-27 anti-tumor activities cause strong inhibition of

Cocco C, Di Carlo E, Zupo S, Canale S, Zorzoli A, Ribatti D, Morandi F, Ognio E, Airoldi I. Leukemia. 2012 Jun;26(6):1365-74.

Widespread potential for growth-factor-driven resistance to anticancer kinase - Widespread potential for growth-factor-driven resistance to anticancer kinase

Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J. Nature. 2012 Jul 26;487(7408):505-9.

IL-27-induced gene expression is downregulated in HIV-infected subjects. - IL-27-induced gene expression is downregulated in HIV-infected subjects.

Guzzo C, Hopman WM, Che Mat NF, Wobeser W, Gee K. PLoS One. 2012;7(9):e45706.

Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 - Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10

Perona-Wright G, Kohlmeier JE, Bassity E, Freitas TC, Mohrs K, Cookenham T, Situ H, Pearce EJ, Woodland DL, Mohrs M. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18535-40. doi:

Interleukin-27 acts as multifunctional antitumor agent in multiple myeloma. - Interleukin-27 acts as multifunctional antitumor agent in multiple myeloma.

Cocco C, Giuliani N, Di Carlo E, Ognio E, Storti P, Abeltino M, Sorrentino C, Ponzoni M, Ribatti D, Airoldi I. Clin Cancer Res. 2010 Aug 15;16(16):4188-97.