| Description |
Insulin protein.Insulin is the most important hormone that inhibitsgluconeogenesis. It acts predominantly by suppressingthe expression of the genes for the key gluconeogenicenzymes pyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G-6-Pase).Insulin is normally secreted by the beta cells (a type ofislet cells) of the pancreas.The development of insulin resistance is an importantmechanism by which obesity leads to the development ofmetabolic and vascular diseases, such as type 2 diabetes,hypertension, dyslipidemia, and cardiovascular diseases,among other medical problems.Recombinant human Insulin produced in E. coli is a twochain, non-glycosylated polypeptide chain containing 51amino acids and having a molecular mass of 5.8 kDa.Recombinant Insulin is purified by proprietarychromatographic techniques.
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