GM-CSF protein

• Supplier: Biorbyt
• Catalog: orb97776
• Category: Protein
• Prices: $451.00
• Sizes: 10 μg
• Species Reactivities: Mouse
• Nature: Recombinant
• Source: P01587
• Purity: > 95% pure by SDS-PAGE and RP-HPLC
• Bioactivity: EC50 Less than 0.2 ng/ml corresponding to a specific activity of 5x106 Units/mg, determined by the dosedependantstimulation of the proliferation of murine FDC-P1 cell line.GM-CSF was lyophilized against 2 mM sodiumphosphate buffer pH 7.4.
• Endotoxin: Less than 0.1 ng/g (IEU/g) of GM-CSF.
• Gene: Csf2
• Description: GM-CSF protein.GM-CSF is produced in response to a number of inflammatory mediators by mesenchymal cells present in thehemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the productionof neutrophilic granulocytes, macrophages, and mixedgranulocyte-macrophage colonies from bone marrow cellsand can stimulate the formation of eosinophil coloniesfrom fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes andmacrophages. GM-CSF receptors shows significant homologies with other receptors for hematopoietic growthfactors, including IL2,IL-3, IL-6, IL-7, EPO, and the Prolactin receptors.Recombinant murine GM-CSF produced in E. coli is a single, non-glycosylated, polypeptide chain containing 125amino acids and having a molecular mass of 14.285kDa.Murine GM-CSF is purified by proprietary chromatographic techniques.