Rat NAP-2 protein

• Supplier: Biorbyt
• Catalog: orb107787
• Category: Protein
• Prices: $221.00, $357.00, $553.00, $910.00
• Sizes: 2 μg, 10 μg, 100 μg, 250 μg
• Applications: SDS-PAGE HPLC
• Species Reactivities: Rat
• Source: E.coli
• Purity: > 97% by SDS-PAGE and HPLC analyses
• Gene: NAP1L4
• Sequence: IELRCRCTNT LSGIPLNSIS RVNVFRPGAH CDNVEVIATL KNGKEVCLDP TAPMIKKIVK KI
• Description: Neutrophil Activating Peptide 2 (NAP-2) is proteolytically processed carboxyl-terminal fragments of platelet basic protein (PBP)which is found in the alpha-granules of human platelets. NAP-2 is a member of the CXC chemokines. Similar to other ELRdomain containing CXC chemokines such as IL-8 and the GRO proteins, NAP-2 has been shown to bind CXCR-2 and tochemoattract and activate neutrophils. Although CTAP-III, C-TG and PBP represent amino-terminal extended variants of NAP-2and possess the same CXC chemokine domains, these proteins do not exhibit NAP-2 activity. Recently, it has been shown thatthe additional amino-terminal residues of CTAP-III masks the critical ELR receptor binding domain that is exposed on NAP-2and may account for lack of NAP-2 activity.