| Name | Rat Activin A |
|---|---|
| Supplier | ABBIOTEC |
| Catalog | 600376 |
| Category | Protein |
| Prices | $250.00 |
| Sizes | 10 µg |
| Species Reactivities | Rat |
| Nature | Recombinant |
| Source | E. coli. Endotoxin level as measured by LAL is <0.05ng/ug or <0.5EU/ug. |
| Purity | Purity > 95% as determined by RP-HPLC and reducing and non-reducing SDS-PAGE. Protein Content determined by UV spectroscopy at 280 nm and analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard. |
| Bioactivity | The activity is determined by the ability to induce cytoxicity of MPC-11 cells and is typically less than 2 ng/mL. Specific activity: 5 x 10e5 units/mg |
| Gene | Inhba |
| Sequence | MGLECDGKVN ICCKKQFFVS FKDIGWNDWI IAPSGYHANY CEGECPSHIA GTSGSSLSFH STVINHYRMR GHSPFANLKS CCVPTKLRPM SMLYYDDGQN IIKKDIQNMI VEECGCS |
| Description | Activin A is a member of the TGFbeta family of proteins produced by many cell types throughout development. Activins interact with Type I and Type II serine/threonine kinases to signal to SMAD proteins to regulate a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, metabolism, etc. Activin A is a homodimer of two beta A chains and is not biologically active until the N terminal propeptide is cleaved from each. Rat Activin A has 100% amino acid sequence identity to human, mouse, porcine, bovine and feline proteins. Rat Activin A is produced in E.coli. Recombinant rat Activin A is a non-glycosylated homodimer, containing two 117 amino acid chains, with a total molecular weight of 26.2 kDa. |
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